The comprehensive guide to the current understanding of galectins
and their promising potential in drug design
This is the first book focusing on galectins. It was inspired by
topics discussed at the symposium ‘Galectins: Structures,
Functions, and Therapeutic Targets’ that was a part of the 234th
American Chemical Society meeting in 2007. To help chemists,
biochemists, and others understand the challenges inherent in the
study of galectins and build on recent advances in the field, the
editors have compiled articles from leading experts on galectins
and their biomedical applications. Galectins includes:
* An overview of early galectin research
* An explanation of the nature of galectins
* A discussion of the structure and functions of galectins, their
ligand specificity and molecular mechanisms of action, and the
localization of galectins in the cell
* An exploration of the roles galectins play in tumor growth and
cancer, fibrosis, inflammation, and immunity
* A discussion of the effect of galectins on cell migration,
angiogenesis, and chemoresistance
* An introduction to new approaches to designing galectin
inhibitors
This is the premier reference on galectins for organic, medicinal,
carbohydrate, and pharmaceutical chemists, biochemists, molecular
and cell biologists, pharmacologists, cancer researchers, and
graduate-level students in these disciplines, as well as clinicians
and drug developers.
Cuprins
Preface.
1. Stumbling on Galectins (Samuel H. Barondes).
2. Galectins and their Functions in Plain Language (Anatole A.
Klyosov).
3. Understanding Galectin Structure-Function Relationships to
Design Effective Antagonists (Irina V. Nesmelova, Ruud P.M. Dings
and Kevin H. Mayo).
4. Galectins as Regulators of Tumor Growth and Invasion by
Targeting Distinct Cell Surface Glycans and Implications for Drug
Design (Hans-J. Gabius and Albert M. Wu).
5. Nuclear and Cytoplasmic Localization of Galectin-1 and
Galectin-3 and their Roles in pre-m RNA Splicing (John L. Wang,
Kevin C. Haudek, Patricia G. Voss and Ronald J. Patterson).
6. Galectins in Regulation of Inflammation and Immunity (Fu-Tong
Liu, Daniel K. Hsu, Ri-Yao Yang, Huan-Yuan Chen and Jun
Saegusa).
7. Galectins as Danger Signals in Host-Pathogen and Host-Tumor
Interactions: New Members of the Growing Group of ‘Alarmins’
(Sachiko Sato and Gabriel Rabinovich).
8. The Role of Galectins in Organ Fibrosis (Neil C. Henderson
and Tariq Sethi).
9. Galectin-1, Cancer Cell Migration, Angiogenesis and
Chemoresistance (Florence Lefranc, Marie Le Mercier, Véronique
Mathieu and Robert Kiss).
10. Galectin-3 in the Progression and Metastasis of Colorectal
Neoplasia (James C. Byrd and Robert S. Bresalier).
11. Galectins in Malignant Gliomas: Expression, Functions and
Possible Therapeutic Options (Herwig M. Strik and Anna
Hoffman).
12. Food-Related Carbohydrate Ligands for Galectins (Valeri V.
Mossine, Vladislav V. Glinsky and Thomas P. Mawhinney).
Index.
Despre autor
Anatole A. Klyosov, Ph D, is Chief Scientist and cofounder of
Pro-Pharma-ceuticals, Inc. He has published more than 290
peer-reviewed articles in scientific journals; authored and edited
books on enzymes, carbohydrates, and biotechnology, including
Wood-Plastic Composites (Wiley); and holds thirty-nine patents.
Zbigniew J. Witczak, Ph D, has extensive industrial and academic
experience in carbohydrates. He has published more than ninety
research papers and holds six patents in the fields of
carbohydrate, medicinal, and biological chemistry. In 2000, Dr.
Witczak was awarded the Melville L. Wolfrom Award of the ACS
Division of Carbohydrate Chemistry for his outstanding research
contribution to carbohydrate chemistry and service to the
division.
David Platt, Ph D, is Chief Executive Officer and cofounder of
Pro-Pharmaceuticals, Inc. He has published peer-reviewed articles
and holds many patents, primarily in the field of carbohydrate
chemistry. Dr. Klyosov, Dr. Witczak, and Dr. Platt coedited the ACS
symposium book Carbohydrate Drug Design.
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