Providing an introduction to isogeometric methods with a focus on their mathematical foundations, this book is composed of four chapters, each devoted to a topic of special interests for isogeometric methods and their theoretical understanding. It contains a tutorial on splines and generalizations that are used in CAD parametrizations, and gives an overview of geometric modeling techniques that can be used within the isogeometric approach, with a focus on non-tensor product splines. Finally, it presents the mathematical properties of isogeometric spaces and spline spaces for vector field approximations, and treats in detail an application of fundamental importance: the isogeometric simulation of a viscous incompressible flow. The contributions were written by Carla Manni and Hendrik Speelers, Vibeke Skytt and Tor Dokken, Lourenco Beirao da Veiga, Annalisa Buffa, Giancarlo Sangalli and Rafael Vazquez, and finally by John Evans and Thomas J.R. Hughes.