Cuprins
Frontmatter – FOREWORD – Official Sponsors and Donors – YOUNG INVESTIGATOR AWARDEES NINTH WORKSHOP ON VITAMIN D – Vitamin D Workshop. Career Recognition Awardees – Contents – Chemistry of Vitamin D – Shape and Conformation of Vitamin D. 11-Fluoro-1a-Hydroxyvitamin D3: The Quest for Experimental Evidence of the Folded Vitamin D Conformation – Conformation and Related Topological Features of Vitamin D: Structure-Function Relationships – Chemical Conversion of Vitamin D3 to Calcitriol Lactone – Design, Synthesis, and SAR of Some 1-Substituted A-Ring Analogs of Calcitriol – A General Synthetic Route to A-Ring Hydroxylated Vitamin D Analogs from D-Pentoses – Retiferols. Design and Synthesis of the New Class of Vitamin D Analogs – Introduction of 1a-Hydroxyl Group to Provitamin D Causes New Photoisomerization Reactions – Synthesis and Determination of the Configurations of the 23-Hydroxylated Metabolites of Calcipotriol (MC 903) and their Epimers – Syntheses of Potential Inhibitors of 25-Hydroxyvitamin D3-1a-Hydroxylase: A-Ring Analogs – Metallic Complexes of Hydroxylated Derivatives of Vitamin D3 – A New Route to the Lythgoe-Roche’s A-Ring Precursor of 1a, 25-Dihydroxyvitamin D3 – Structure-Activity Studies of Fluorinated Vitamin D Analogs – An In Vitro Model of Previtamin D Photosynthesis as Possible Monitor of Ozone Depletion – Synthesis of 24-Hydroxy-Vitamin D Analogues – Chromatographic Isolation and Spectroscopic Characterization of the Photoisomers of 1a, 25-Dihydroxy-Provitamin D3 – A New Route to the Vitamin D Triene System – Studies on the Synthesis of 19-Norprevitamin D3 Analogues – Structure/Function Studies of Vitamin D Steroids – The Need for New Vitamin D Analogues: Mechanisms of Action and Clinical Applications – Future Prospects for Vitamin D Analogs – Chemistry and Biology of 22, 23-yne Analogs of Calcitriol – Chemistry and Biology of 23-oxa-aro- and 23-thia-aro-Vitamin D Analogues with High Antiproliferative and Low Calcemic Activity – Activity of Vitamin D Analogs in Co-Transfected COS-7 Cells – Synthesis and Biological Character of 1?-Hydroxylated Vitamin D3 Analogs – Biological Activity and Conformational Analysis of 1?, 25-Dihydroxyvitamin D3 and its Analogues – Topological Mimics of the 6-s-cis-Conformer of 1a, 25-Dihydroxyvitamin D3 Based on the Provitamin D Skeleton – Chemistry and Biology of Highly Active 22-oxy Analogs of 20-epi Calcitriol with Very Low Binding Affinity to the Vitamin D Recepto – New Discoveries in Vitamin D Related Compounds – Modelling of Previtamin D Photosynthesis in View of its Conformational Flexibility – Active Vitamin D Analogs with Side Chain Hydroxyl Group Occupying Diverse Spatial Region – Synthesis and Biological Activity of 23-oxa Vitamin D Analogues – Synthesis and Biological Activity of 20-Hydroxylated Vitamin D Analogues – 20-Methyl Vitamin D Analogues – 2?-Substituted Calcitriols and Other A-Ring Substituted Analogues – Synthesis and Biological Results – Syntheses and Biological Activity of 1ß-Substituted Active Vitamin D3 Analogs – Vitamin D Binding Protein – Probing the Vitamin D-Sterol Binding Domain of Human Vitamin D-Binding Protein: Chemical Modification of Specific Amino Acid Residues – Crystallization and Preliminary X-Ray Investigation of Vitamin D-Binding Protein from Human Serum – Effects of Vitamin D-Binding Proteins on Biological Functions of 1 a, 25-Dihydroxyvitamin D3 Analogues – Vitamin D Hydroxylases: Biochemistry and Regulation – Differences of the Regulation of 24-Hydroxylase Gene Expression in the Kidney and Intestine – Regulation of the Ferredoxin Component of Renal Hydroxylases at the Transcriptional and Postradiational Level and of the Protein Inhibitor of Cyclic AMP-Dependent Kinase – Site and Rate of Hydroxylation of 1a-OH-D3 Analogs by CYP27 Not Altered by Increasing Length or Changing Orientation of Vitamin D3 Side Chain – Protein Kinase C Up-Regulates 1 a, 25-Dihydroxyvitamin D3-Induced Expression of
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