This authoritative work, now thoroughly revised, has given thousands of clinicians, students, and researchers a state-of-the-art understanding of the human frontal lobes–the large brain region that plays a critical role in behavior, cognition, health, and disease. Leading experts from multiple disciplines address the anatomy and chemistry of the frontal cortex, neuropsychological assessments of capabilities unique to the frontal lobes, the nature of (and possible treatment avenues for) frontotemporal dementia and related conditions, and implications for understanding and treating neuropsychiatric disorders, such as schizophrenia, mania, and depression. Illustrations include eight pages in full color. New to This Edition: *Reflects a decade of important research advances in such areas as functional connectivity mapping of frontal and frontal-subcortical circuits. *Incorporates significant new information on frontotemporal dementia and other neurological disorders. *Expanded section on neuropsychiatric disorders, with new chapters on apathy, dissociative states, and antisocial behavior. *Chapters on salience networks, normal brain aging, white matter diseases, and clinical trials. *Increased attention to brain processes involved in moral reasoning, empathy, decision making, and other key human capabilities.
Cuprins
I. Neuroanatomy and Neurochemistry 1. The Human Frontal Lobes: An Introduction, Bruce L. Miller and Jeffrey L. Cummings 2. The Mesocortical Dopaminergic System, Billy T. Chen and Antonello Bonci 3. The Dorsolateral and Cingulate Cortex , James R. Bateman and Daniel I. Kaufer 4. The Orbitofrontal Cortex and the Insula, Eun-Joo Kim, Jennifer Ogar, and Maria Luisa Gorno-Tempini 5. Structural and Functional Asymmetries of the Human Frontal Lobes, Daniel H. Geschwind and Marco Iacoboni 6. Gross Morphology and Architectonics, Helmut Heinsen and Lea Tenenholz Grinberg II. Assessment: Neuropsychology and Behavior 7. The Frontal Lobes and Executive Control, Adam Gazzaley, Taraz G. Lee, and Mark D’Esposito 8. Bedside Frontal Lobe Testing, Adam M. Staffaroni, Melanie L. Stephens, and Joel H. Kramer 9. The Prefrontal Cortex and Human Memory, Nick Diamond and Brian Levine 10. Language and Frontal Cortex, Marlís González-Fernández and Argye E. Hillis 11. Self-Awareness and Frontal Lobe Networks, Virginia E. Sturm, Alice Y. Hua, and Howard J. Rosen 12. Decision-Making Capacity and Frontal Lobe Dysfunction, Sarah M. Hooper and Winston Chiong 13. Socioemotional Functioning and Frontal Lobe Injury, Katherine P. Rankin, Kelly Gola, and Tracy L. Jerard 14. Salience Networks: Magnetic Resonance Imaging Interrogation of Self-Concepts in Dementia, Winston Chiong III. Neurological Diseases Section A: FTD and Related Disorders 15. Clinical Aspects of Frontotemporal Dementia, David C. Perry and Bruce L. Miller 16. Progressive Supranuclear Palsy, Corticobasal Degeneration, and the Frontal Cortex, Anne-Catherine Vijverman, Maria Carmela Tartaglia, and Anthony E. Lang 17. Neuropathology of Frontotemporal Dementias, Nigel J. Cairns, David J. Irwin, Vivianna M. Van Deerlin, Virginia M.-Y. Lee, and John Q. Trojanowski 18. Frontotemporal Dementia Neurogenetics, Leonel T. Takada Section B: Other Disorders 19. Normal Aging of the Frontal Lobes, Brianne Bettcher 20 . Vascular Cognitive Impairment: Executive Dysfunction in the Era of the Human Brain Connectome, Helena C. Chui and Liliana Ramirez Gomez 21. White Matter Diseases of the Frontal Lobes, Christopher M. Filley 22 . Parkinson’s Disease, Parkinson’s Disease with Dementia, and Dementia with Lewy Bodies, Jee Bang, Sharon J. Sha, and Katherine L. Possin 23. Traumatic Brain Injury, Judith Aharon-Peretz IV. Neuropsychiatric Disorders 24. Prefrontal Cortical Dysfunction in Schizophrenia: Clinical Implications and Novel Treatment Development, Daniel Fulford, Joshua D. Woolley, and Sophia Vinogradov 25. Mania and the Frontal Lobes, Mary G. De May and Bruce L. Miller 26. Obsessive–Compulsive Disorder, Edwin H. Rodriguez and Carol A. Mathews 27 . Depression and the Frontal Lobes, Ira Lesser, Julia Chung, and Weiguo Zhu 28. Apathy, Georges Naasan 29 . Frontal Lobe Seizures, Frontal Cortex, and Dissociative States, Anli Liu and Orrin Devinsky 30 . The Role of the Frontal Lobes in Antisocial and Aggressive Behavior: Review of the Research and Legal Implications, Annette L. Ermshar and Kyle Brauer Boone V . Treatment 31. Neurosurgical Treatments for Psychiatric Disorders, Simon Ducharme, Darin D. Dougherty, and Bruce H. Price 32 . Clinical Trials in Frontotemporal Lobar Degeneration, Gabriel C. Léger, Sarah J. Banks, and Jeffrey L. Cummings Index
Despre autor
Bruce L. Miller, MD, is the A. W. and Mary Margaret Clausen Distinguished Professor of Neurology at the University of California, San Francisco (UCSF), and Director of the UCSF Memory and Aging Center. Dr. Miller is a behavioral neurologist focused on dementia, with special interests in brain-behavior relationships as well as the genetic and molecular underpinnings of disease. He currently conducts research on frontotemporal dementia, oversees a program on healthy aging, and helps lead two privately funded research consortia. Dr. Miller is a recipient of the Potamkin Prize from the American Academy of Neurology, the Raymond D. Adams Lectureship from the American Neurological Association, the J. Elliot Royer Award from the San Francisco Neurological Society, the UCSF Annual Faculty Research Lectureship in Clinical Science, and the Gene D. Cohen Research Award in Creativity and Aging from the National Center for Creative Aging, among many other honors. With more than 700 scientific publications, Dr. Miller has served since 1984 as Scientific Director of the John Douglas French Alzheimer’s Foundation. He is a member of the National Academy of Medicine. Jeffrey L. Cummings, MD, Sc D, is Director of the Cleveland Clinic Lou Ruvo Center for Brain Health in Las Vegas, Nevada, and Cleveland, Ohio. He is the Camille and Larry Ruvo Chair for Brain Health at the Cleveland Clinic Neurological Institute and Professor of Medicine at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. A leading authority on Alzheimer’s disease, Dr. Cummings is interested in clinical trials, developing new therapies for brain diseases, and the interface of neuroscience and society. He is a recipient of the Edward Henderson Award from the American Geriatrics Society, the Research Award from the John Douglas French Alzheimer’s Foundation, the Ronald and Nancy Reagan Research Institute Award from the Alzheimer’s Association, the Distinguished Scientist Award from the American Association for Geriatric Psychiatry, and the Lifetime Achievement Award from the Society for Behavioral and Cognitive Neurology, among many other honors. Dr. Cummings has more than 700 scientific publications and is a past president of the Behavioral Neurology Society and the American Neuropsychiatric Association.
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