The book presents recent advances relating to the factors and mechanisms that regulate the growth, differentiation and function of mast cells and basophils; discussion of new technologies used to study these cells, and integration of the basic scientific findings in the context of therapeutic possibilities for the treatment of diseases such as allergic inflammation and autoimmune disease which are mediated, in part, by these granulocytes.
Cuprins
Symposium on Mast cells and basophils: development, activation
and roles in allergic/autoimmune disease, held at the Novartis
Foundation, London, 16-18 November 2004
Editors: Derek J. Chadwick (Organizer) and Jamie Goode
This symposium was based on a proposal made by Santa Jeremy
Ono.
Santa Jeremy Ono: Chair’s Introduction.
Yukihiko Kitamura MITF and Sg IGSF: an essential
transcription factor and its target adhesion molecule for
development and survival of mast cells
Discussion.
Paul J. Bryce, Mendy L. Miller, Ichiro Miyajima, Mindy Tsai,
Stephen J. Galli and Hans C. Oettgen: Immune
sensitization in the skin is enhanced by antigen-independent
effects of Ig E on mast cells
Discussion.
Yasuko Furumoto, Gregorio Gomez, Claudia Gonzalez-Espinosa,
Martina Kovarova, Sandra Odom, John J. Ryan and Juan
Rivera: The role of Src family kinases in mast cell effector
function
Discussion.
Richard L. Stevens, Nasa Morokawa, Jing Wang and
Steven A. Krilis: Ras GRP4 in mast-cell signalling and
disease susceptibility
Discussion.
J. Abramson, E. A. Barbu and I. Pecht: Regulation
of mast cell secretory response to the type I Fce receptor:
inhibitory elements and desensitization
Discussion.
General discussion I.
Toshiaki Kawakami, Jiro Kitaura, Wenbin Xiao and Yuko
Kawakami: Ig E regulation of mast cell survival and
function
Discussion.
See-Ying Tam, Janet Kalesnikoff, Susumu Nakae, Mindy Tsai
and Stephen J. Galli: Rab GEF1, a negative regulator of Ras
signalling, mast cell activation and skin inflammation
Discussion.
Masako Toda, Takao Nakamura, Masaharu Ohbayashi, Yoshifumi
Ikeda, Maria Dawson, Ricardo Micheler Richardson, Andrew Alban,
Benjamin Leed, Dai Miyazaki and Santa Jeremy Ono: Role
of CC chemokines and their receptors in multiple aspects of mast
cell biology: comparative protein profiling of Fce RI- and/or
CCR1-engaged mast cells using protein chip technology
Discussion.
General discussion II.
Shigeo Koyasu, Akiko Minowa, Yasuo Terauchi, Takashi
Kadowaki and Satoshi Matsuda: The role of
phosphoinositide-3-kinase in mast cell homing to the
gastrointestinal tract
Discussion.
K. Frank Austen: The mast cell and the cysteinyl
leukotrienes
Discussion.
Silvia Monticelli, K. Mark Ansel, Dong U. Lee and
Anjana Rao: Regulation of gene expression in mast cells:
micro-RNA expression and chromatin structural analysis of cytokine
genes
Discussion.
Cellina Cohen-Saidon and Ehud Razin: The
involvement of Bcl-2 in mast cell apoptosis
Discussion.
General discussion III.
P. A. Nigrovic and D. M. Lee: Mast cells in
autoantibody responses and arthritis
Discussion.
Greg D. Gregory, Allison Bickford, Michaela Robbie-Ryan,
Mindy Tanzola and Melissa A. Brown: MASTering the immune
response: mast cells in autoimmunity
Discussion.
Dean D. Metcalfe: Mastocytosis
Discussion.
Index of Contributors.
Subject Index.
Despre autor
The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.
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