Although normally thought of as a sex hormone, recent research has
highlighted the numerous and significant effects that oestrogen has
on the CNS, extending far beyond its important reproductive role.
It has been shown that oestrogen acts as a neural growth factor
with important influences on the survival, plasticity, regeneration
and ageing of the mammalian brain.
This exciting book brings together leading clinicians and
researchers to discuss oestrogen’s basic mechanisms of action, the
extrahypothalmic brain regions it affects, and its influence on
cognitive functions in animals and humans. Finally, recent research
on the role of oestrogens in ageing and dementia, including the
significance of oestrogen action in Alzheimer’s disease, is
discussed. The 15 papers contained in this book, together with the
extensive discussion sessions that follow them, reveal much new and
exciting work in this area, and identify promising new research
directions.
Cuprins
Chairman’s Introduction (B. Mc Ewen).
Mechanism of Oestrogen Signalling with Particular Reference to
the Role of ERß in the Central Nervous System (E. Treuter,
et al.).
Oestrogen Receptor Function at Classical and Alternative
Response Elements (P. Kushner, et al.).
GENERAL DISCUSSION I.
Nuclear Receptor Versus Plasma Membrane Oestrogen Receptor (E.
Levin).
Novel Sites and Mechanisms of Oestrogen Action in the Brain (C.
Toran-Allerand).
Oestrogen Modulation of Noradrenaline Neurotransmission (A.
Herbison, et al.).
Oestrogen and the Cholinergic Hypothesis: Implications for
Oestrogen Replacement Therapy in Postmenopausal Women (R.
Gibbs).
Ovarian Steroid Action in the Serotonin Neural System of
Macaques (C. Bethea, et al.).
Oestrogen Effects on Dopaminergic Function in Striatum (J.
Becker).
GENERAL DISCUSSION II.
Oestrogen Effects in Olivo-Cerebellar and Hippocampal Circuits
(S. Smith, et al.).
Effects of Oestradiol on Hippocampal Circuitry (C. Woolley).
Oestrogen and Cognitive Function Throughout the Female Lifespan
(B. Sherwin).
Neuroprotective Effects of Phenolic A Ring Oestrogens (P. Green,
et al.).
The Female Sex Hormone Oestrogen as Neuroprotectant: Activities
at Various Levels (C. Behl, et al.).
Neurohormonal Signalling Pathways and the Regulation of
Alzheimer ß-Amyloid Metabolism (S. Gandy & S.
Petanceska).
Oestrogens and Dementia (V. Henderson).
Indexes.
Despre autor
Derek J. Chadwick and Jamie A. Goode are editors for Neuronal and Cognitive Effects of Oestrogens and other scientific titles.
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