This issue of Veterinary Clinics: Small Animal Practice, guest edited by Dr. Elisa Mazzaferro, focuses on Emergency and Critical Care of Small Animals. This is one of six issues each year. Articles in this issue include, but are not limited to: Cardiopulmonary Resuscitation in Small Animals; Transfusion Medicine in Small Animals; Extracorporeal Therapies in the ER and ICU; Respiratory Emergencies; Ocular Emergencies in the Small Animal Patient; Biosecurity Measures in Small Animal Practice; Albumin Therapy in Critical Illness; Canine Parvoviral Enteritis; Therapeutic Strategies in IMHA; Use of Antithrombotics in Critical Illness; Use of Intravenous Immunoglobulin in Clinical Practice; Use of Intravenous Immunoglobulin in Clinical Practice; Resuscitative Strategies for the Small Animal Trauma Patient; Use of Thromboelastography in Clinical Practice; Nutritional Support of the Critical Patient; Update on Anticonvulsant Therapy for the Small Animal Patient; Total Intravenous Anesthesia for the Small Animal Critical Patient; and Cageside Ultrasound in the ER and ICU.