Vitamin E was discovered in 1922 by Evans and Bishop as an essential micronutrient for reproduction in rats. The active substance was isolated in 1936 by Evans and was named tocopherol, although the tocopherols and tocotrienols are actually a group of eight isomeric molecules that are characterized by a chromanol ring structure and a side chain.
Providing an overview of the state-of-the-art of the chemistry of vitamin E, this book reflects the issues stemming from the complexity of the role and actions in vivo as well as in vitro. It summarizes information on the properties and function of vitamin E, the current understanding of the advantages and limitations of it, and also its application in promotion of health and prevention of diseases. Based on sound, solid scientific evidence, this is a timely addition to the literature as the centennial anniversary of the discovery of this important vitamin approaches.
Cuprins
Vitamin E: Structure, Properties and Functions;
Tocotrienols: From Bench to Bedside;
The Behaviour of Vitamin E in Membranes;
Chemical Reactivity and Cellular Uptake of Tocopherols and Tocotrienols;
α-Tocopherol Transfer Protein;
Tocopheryl Phosphate;
Novel Functions of Vitamin E Nicotinate;
Reactive Oxygen Species in Biological Systems;
Lipid Peroxidation: Role of Vitamin E;
Antioxidant Defense Network and Vitamin E;
Vitamin E Inspired Synthetic Antioxidants;
Action of Vitamin E Against Lipid Peroxidation and Cell Death;
Oxidation Products of Vitamin E with Lipid-derived Free Radicals;
Metabolism of Vitamin E;
Analysis of Vitamin E Metabolites;
Essentiality, Bioavailability, and Health Benefits of α-Tocopherol Stereoisomers;
Vitamin E Deficiency and Inadequacy;
Insights Using Zebrafish, Lipidomics and Metabolomics;
Interference Effect of Vitamin E on Vitamin K Metabolism
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