Medicinal Chemistry: An Introduction, Second Edition
provides a comprehensive, balanced introduction to this evolving
and multidisciplinary area of research. Building on the success of
the First Edition, this edition has been completely revised and
updated to include the latest developments in the field.
Written in an accessible style, Medicinal Chemistry: An
Introduction, Second Edition carefully explains fundamental
principles, assuming little in the way of prior knowledge. The book
focuses on the chemical principles used for drug discovery and
design covering physiology and biology where relevant. It opens
with a broad overview of the subject with subsequent chapters
examining topics in greater depth.
From the reviews of the First Edition:
‘It contains a wealth of information in a compact form’
ANGEWANDTE CHEMIE, INTERNATIONAL EDITION
‘Medicinal Chemistry is certainly a text I would chose to
teach from for undergraduates. It fills a unique niche in the
market place.’ PHYSICAL SCIENCES AND EDUCATIONAL REVIEWS
Cuprins
Preface
Acknowledgements.
Abbreviations.
Chapter 1. An Introduction to Drugs, their Action and Discovery.
Chapter 2. Drug Structure and Solubility.
Chapter 3. Structure-activity and quantitative structures relationships.
Chapter 4. Computer aided drug design.
Chapter 5. Combinatorial Chemistry.
Chapter 6. Drugs from natural sources.
Chapter 7. Biological Membranes.
Chapter 8. Receptors and Messengers.
Chapter 9. Enzymes.
Chapter 10. Nucleic Acids.
Chapter 11. Pharmacokinetics.
Chapter 12. Drug metabolism.
Chapter 13. Complexes and chelating agents.
Chapter 14. Nitric oxide.
Chapter 15. An Introduction to drug and analogue synthesis.
Chapter 16. Drug Development and Production.
Selective further reading.
Answers to Questions.
Index.
Despre autor
Dr Gareth Thomas, The University of Portsmouth, UK.
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