Is noninvasive, risk-free prenatal diagnosis of fetal genetic characteristics still a fantasy, or will it soon become reality? The current status of both the leading European research groups as well as the NIH-funded NIFTY study are reported here, indicating that certain fetal genetic traits can now be examined efficiently in a noninvasive manner. Considerable focus is placed on new laser-mediated systems for the effective micro-manipulation of single fetal cells, as well as their analysis by single-cell PCR and the pitfalls to avoid when performing such analyses. Other issues addressed in depth include: novel enrichment techniques, optimal fetal cell recognition, fetal cell culture, as well as the exciting finding that fetal cell traffic is elevated in certain pregnancy-related disorders, most prominently in preeclampsia. This publication is of interest to researchers in the field, genetic counsellors, gynecologists and obstetricians, and researchers in microchimerism, transplantation and transfusion medicine.
Mai multe cărți electronice de la același autor (i) / Editor
46.657 Ebooks din această categorie
