Autor: Hendrik Timmerman

Most drugs bind to a clearly defined macromolecular target that is complementary in terms of structure and chemistry. This observation is the basic paradigm of structure-based ligand design. Although …

Recent progress in high-throughput screening, combinatorial chemistry and molecular biology has radically changed the approach to drug discovery in the pharmaceutical industry. New challenges in synt …

Quantitative studies on structure-activity and structure-property relationships are powerful tools in directed drug research. In recent years, various strategies have been developed to characterize a …

When trying to find new methods and problem-solving strategies for their research, scientists often turn to nature for inspiration. An excellent example of this is the application of Darwin’s Theory …

Kurz vor der Jahrtausendwende hat die Synthesechemie nochmals einen signifikanten Innovationsschub erfahren: Die effiziente Herstellung einer Vielfalt von neuen Verbindungen hat durch den Vormarsch d …

Written by experienced experts in molecular modeling, this books describes the basics to the extent that is necessary if one wants to be able to reliably judge the results from molecular modeling cal …

Lipohilie ist der Schlüssel zum Verständnis der Wirksamkeit von Medikamenten. Trotz ihrer Bedeutung wird diese entscheidende Eigenschaft aber vielfach noch nicht genügend gewürdigt oder verstanden. I …

The statistical analysis of experimental and theoretical data lies at the heart of modern drug design. This practice-oriented handbook is a comprehensive account of modern chemometric methods in mole …

The use of powerful computers has revolutionized molecular design and drug discovery. Thoroughly researched and well-structured, this comprehensive handbook covers highly effective and efficient tech …

QSAR ist ein Akronym für ‘quantitative Struktur-Wirkung- Beziehung’. Dahinter verbergen sich Methoden, die sich nichts Geringeres zum Ziel gesetzt haben, als neue Medikamente zur Behandlung bestimmte …