This is the very first book to focus on this new approach that will eventually aid in developing new diagnostic markers and therapies for controlling and treating heart disease – the number-one killer in the industrialized world.
Divided into two parts, the book describes not only the potentials, but also the limitations of these technologies. The editors, both well known within the scientific community, provide new insights into the biochemical and cellular mechanisms of cardiovascular disease, as well as covering the transition into clinical applications. In so doing, they highlight the various strategies and technical aspects so as to assist the growing number of researchers intending to utilize these approaches. The result is an excellent way of educating and informing graduate students, post-doctoral fellows as well as researchers in academia and industry about the latest developments in this area.
Cuprins
GENOMICS
Large scale expression profiling in cardiovascular disease using microarrays: prospects and pitfalls
Global Genomic Analyses of Cardiovascular Disease: A Potential Map or Blind Alley?
Heart Failure: A Genomics Perspective
Experimental application of the genomic microarray analysis of both human and animal models of heart failure
Gene Profiling in the Heart by Subtractive Hybridization
DNA Mircoarray Gene Profiling: A Tool for the Elucidation of Cardioprotective Genes
Pitfalls Associated With c DNA Microarrays; A Cautionary Tale
Application of Biologic Skepticism to Analysis of Expression Phenotypes
Genes involved in atherosclerosis and plaque formation
PROTEOMICS
Proteomics of the Cardiovascular Disease – A Step Beyond Genomics
Mass spectrometry – A Powerful Analytical Tool
Differential Expression Proteomic Analysis Using Isotope Coded Affinity Tags
Protein chip technology in proteomics analysis
Recent Applications of Functional Proteomics: investigations in smooth muscle cell physiology
Gene Expression Profiling in Pulmonary and Systemic Vascular Cells Exposed to Biomechanical Stimuli
Identification of Targets of Phosphorylation in Heart Mitochondria
Proteomic Characterization of Protein Kinase C Signaling Tasks in the Heart
Identification of Secreted Oxidative Stress-Induced Factors (SOXF) and Associated Proteins: Proteomics in Vascular Biology
Myofilament proteomics: understanding contractile dysfunction in cardiorespiratory disease
FUTURE PERSPECTIVES
Genomics Perspective for Drug Discovery
Proteomics: A Post-Genomic Platform for Drug Discovery and Development
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