This book uses an interdisciplinary inter-mediational approach to reflect on the relational complexity of unsettlement as a predominant sensibility of the present epoque.The book tackles interrelated aspects of unsettlement including temporality, the disconcerting effects of the Anthropocene, the biomedical facets of unsettlement, and the post-pandemic futures. It uses a chimeric approach combining essayistic and speculative fiction writing methods, negotiating rational, affective and imaginative ways of inquiry, and showing rather than merely explaining. The book poses questions, but gives no ready-made answers, and invites us to think together on the unsettlement as a negatively global human condition that can be collectively made into a generative move of resurgence and refuturing.Contributing to critical reflections on the main features and sensibilities of the current epoque, the book will be of interest to scholars and undergraduate and graduate students, as well as the general public, interested in critical global and future perspectives, in decolonial research, gender studies, and posthumanities.