In this timely new contribution, Koehn and Rosenau develop their transnational-competence framework and demonstrate the promise of its application across six critical professions: teacher education, engineering, business management, social work, sustainable-development (encompassing agricultural sciences, public administration, and natural-resources management), and medicine/health. Transnational Competence offers higher-education leaders around the world useful ideas for enhancing and transforming professional programs so that graduating practitioners will be prepared with the skills needed to manage horizon-rising challenges that connect populations, ecosystems, and fields of study. Aimed principally at higher-education leaders and graduating professionals throughout the world, Transnational Competence focuses on the skills that tomorrow’s practitioners will need to deal with what the authors term horizon-rising transboundary challenges.