Philip L. Fuchs 
Reagents for Silicon-Mediated Organic Synthesis [PDF ebook] 

Over the last three decades the importance of organosilicon
chemistry has greatly increased because it has opened a number of
new synthetic strategies. Silicon reagents are usually low-cost,
versatile and allow a wide range of reactions. This is the first
Handbook to compile essential Silicon containing reagents and makes
use of the leading reagent database e-EROS. Another hot
volume in the series Handbooks of Reagents for Organic
Synthesis, this is a must-have resource for all synthetic
chemists working in drug development and medicinal chemistry.
For the selection the Editor focussed on three key synthetic
approaches with the greatest impact:
1. Use of silicon as a ‘temporary tether’ by unifying a reactive
pair of functional groups and taking advantage of their
template-biased intramolecular cyclization.
2. The specific use of the silane functionality as a hetero
t-butyl group, often colloquially referred to as the use of
silicon as a ‘fat proton’.
3. The use of the Brook rearrangement as an ‘anion relay
stratagem’.
A new feature in this Handbook is the reagent finder, an
alphabetically organized lookup table arranged by organic
functionality and specific structure of the silicon atom to which
it is bound.

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