This book constitutes the proceedings of the 19th IFIP WG 10.3 International Conference on Network and Parallel Computing, NPC 2022, which was held in Jinan, China, during September 24-25, 2022.The 23 full papers and 8 short papers presented in this volume were carefully reviewed and selected from 89 submissions. They were organized in topical sections as follows: computer architecture; cloud computing; deep learning; emerging applications; and storage and IO.