mi RNAs are a class of endogenous, small non-protein coding RNA molecules (~ 22 nucleotides) which are novel post-transcriptional regulators of gene expression. Since we have hundreds of mi RNAs, the major challenge is now to understand their specific biological function. In fact the experimental evidence suggests that signaling pathways could be ideal candidates for mi RNA-mediated regulation. Several studies suggest that mi RNAs affect the responsiveness of cells to signaling molecules such as WNT, Notch, TGF-β and EGFR. Altered expression of particular mi RNAs has been implicated in the onset and development of cancer and could be used as potential biomarkers for the disease.
Recently, many studies have found mi RNAs have crucial regulatory roles in Cancer stem cells (CSCs) a kind of tumor initiating cells (TICs) and dormancy. Findings also suggest that DNA methylation may be important in regulating the expression of many mi RNAs in several cancer initiating cells. Several mi RNAs are known to either upregulated or downregulated in CSCs when compared to non-cancerous cells from the same tissues. CSCs are a small subpopulation of cells identified in a variety of tumors and involve in self-renewal, differentiation, chemoresistance and tumorigenesis. The volume will give a comprehensive account of important advancements in the area of mi RNAs and cancer.
Cuprins
Preface.- mi RNA biogenesis and function.- mi RNAs in cancer progression.- Micro RNA, DNA repair and cancer.- Role of micro RNAs in stem cells regulation and tumorigenesis in Drosophila.- Micro RNAs in stem cells and cancer stem cells.- Micro RNAs in epithelial mesenchymal transition and breast cancer progression.- Micro RNAs in the development and progression of breast cancer.- The role of micro RNAs in hematopoietic stem cells and leukemia development.- Mi RNA and chronic lymphocytic leukemia.- The role of mi RNAs in the development of normal pancreas and pancreatic cancer, and their roles in tumor progression.- Epigenetic regulation of micro RNA genes in colorectal cancer.- Micro RNAs in the development and progression of kidney cancer.- Micro RNAs in the development and progression of skin cancer.- Micro RNAs in the Development and Progression of Prostate Cancer.- Micro RNAs in development and progression of ovarian cancer.- Micro RNA and Cancer Drug Resistance.- Microvesicular Transfer of micro RNA in Tumor Microenvironment.- Micro RNA cancer therapeutics and the challenge of drug delivery.- Micro RNA and Drug Delivery.- Index.
Despre autor
Dr. Shree Ram Singh is a Staff Scientist for the Mouse Cancer Genetics Program at the National Cancer Institute.
Dr. Pranela Rameshwar is a Professor of the Department of Medicine at UMDNJ-New Jersey Medical School. See attached CV for additional details.
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