Ig G4-related disease (Ig G4-RD) is an increasingly recognized and novel systemic inflammatory disorder characterized by tumefactive lesions with infiltrating Ig G4-positive plasma cells. The disease affects virtually every organ system. Immunologically, plasmablasts increase in patients with Ig G4-RD in which activation and dysregulation of B cells may be involved. Accurate characterization by a method using various modalities and immunological evaluation including plain radiography, ultrasound, CT, scintigraphy, MRI and flow cytometry should be required. Comprehensively, we review and illustrate the systemic and organ-specific findings of Ig G4-RD. This book shows a systematic and organ-specific evaluation of immunological and radiological findings for general practitioners. Moreover, the book is also interesting for the subspecialists including rheumatologists, dermatologists, otologists, respiratory physicians, clinical immunologists and radiologists, and patients and their families because patients with Ig G4-RD visits every subspecialist by the tremendous various clinical symptoms and findings. The study in the book included 147 patients with Ig G4-RD who visited Saga University Hospital froma January 1, 2001 to March 31, 2020. Although the number of patients studied in this monograph was not so large, the patients evaluated and treated by a single institution are considered clinically valuable.
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