This second edition expands upon and updates the vital research covered in its predecessor, by presenting state-of-the-art multidisciplinary and systems-oriented approaches to complex diseases arising from and driven by the acute inflammatory response. The chapters in this volume provide an introduction to different types of computational modeling, and how these methods can be applied to specific inflammatory diseases, with a focus on providing readers a roadmap for integrating advanced mathematical and computational techniques with traditional experimental methods. In this second edition, we cover both well-established and emerging modeling methods, especially state-of-the-art machine learning approaches and the integration of data-driven and mechanistic modeling.
This volume introduces the concept of Model-based Precision Medicine as an alternative approach to the current view of Precision Medicine, based on leveraging mechanistic computational modeling to decrease cost while increasing the information value of the data being obtained.
By presenting the role of computational modeling as an integrated component of the research process, Complex Systems and Computational Biology Approaches to Acute Inflammation: A Framework for Model-based Precision Medicine offers a window into the recent past, the present, and the future of computationally-augmented biomedical research.
Cuprins
1. An Overview of the Translational Dilemma and the Need for Model-based Precision Medicine.- 2 Translational Equation-based Modeling.- 3. Agent-based Modeling in Translational Systems Biology.- 4. Integrating Data-driven and Mechanistic Modeling in Sepsis and Trauma.- 5. Therapeutics as Control: Model-based approaches for control discovery.- 6. Disorder of Systemic Inflammation in Sepsis and Trauma: A Systems Perspective.- 7. Multi-scale equation-based models: Insights for Inflammation and Physiological Variability.- 8. In silico Trials and Personalized Therapy for Sepsis and Trauma.- 9. Computational Modeling of the Coagulation Response.- 10. Disorder of Localized Inflammation in Wound Healing.- 11. Equation-based Models of Wound Healing and Collective Cell Migration.- 12. Agent-based Models of Wound Healing.- 13. Tissue realistic translational modeling of gut inflammation.- 14. Data-Driven Modeling of Liver Injury, Inflammation, and Fibrosis.- 15. Computational Modeling of Tuberculosis.- 16. The Rationale and Implementation of Model-based Precision Medicine for Inflammatory Diseases.- Index.
Despre autor
Dr. Yoram Vodovotz is currently a Professor of Surgery, Immunology, Computational and Systems Biology, Bioengineering, Clinical and Translational Science, and Communication Science and Disorders at the University of Pittsburgh School of Medicine. His research focus is the systems biology of inflammation. He is the Director of the Center for Inflammation and Regeneration Modeling at the Mc Gowan Institute for Regenerative Medicine, a co-founder and past President of the Society for Complex Acute Illness, and a co-founder of Immunetrics, Inc., a Pittsburgh-based company that is commercializing this mathematical modeling work. He has published over 300 manuscripts, including three books.
Dr. Gary An is a Professor of Surgery and Vice-Chairman for Surgical Research in the Department of Surgery at the University of Vermont Larner College of Medicine. He is a founding member of the Society of Complexity in Acute Illness and past president of the Swarm Development Group, one ofthe original organizations promoting the use of agent-based modeling for scientific investigation. In addition to being an active trauma/critical care surgeon he has worked on the application of complex systems analysis to sepsis and inflammation since 1999 and consists of development of mechanism-based computer simulations and integration of machine learning and artificial intelligence with multi-scale simulation models for discovery of therapeutic control modalities.
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