Animal models and tests have become increasingly important for biomedical research, enabling a better understanding of pathogenic pathways involved in various human disorders. Over the last decades, zebrafish (Danio rerio) have become a very popular model organism in biomedical research. Recently, this fish has entered the waters of neuroscience and biological psychiatry, quickly becoming an indispensable model species in this field. With a high genetic homology to humans (~75% based on coding regions), it is not surprising that humans and fish are very similar physiologically (and behaviorally).
Therefore, it should not come as a surprise that zebrafish can be an excellent model of human neuropsychiatric disorders. While some classical psychiatrists may not too easily be persuaded by this generalization, the current book “The rights and wrongs of zebrafish: principles of behavioral phenotyping and CNS disease modeling” explains, in a domain-by-domain manner, how exactly zebrafish models can be used to target a wide range of human brain disorders and aberrant phenotypes.
The contributors to this book are leading international scholars whose work spearheads innovative zebrafish neuroscience research around the world. Written by top experts in the field, this book makes for a useful, balanced and up-to-date reading that outlines the use of zebrafish to study the pathological mechanisms underlying neuropsychiatric disorders.
Содержание
Preface.- Mutagenesis and transgenesis in zebrafish.- Developing zebrafish depression-related models.- Zebrafish models of anxiety-like behavior.- Assessing cognitive phenotypes in zebrafish.- Social phenotypes in zebrafish.- Modeling OCD endophenotypes in zebrafish.- Zebrafish models of attention-deficit/hyperactivity disorder (ADHD).- Zebrafish neurotoxicity models.- Sleep phenotypes in zebrafish.- Zebrafish neurobehavioral assays for drug addiction research.- Zebrafish behavioral models of ageing.- Integrating morphological and behavioral phenotypes in developing zebrafish- Neuroimaging phenotypes in zebrafish.- Illustrated zebrafish neurobehavioral glossary.- Index.
Об авторе
Allan V. Kalueff is Professor of Translational Biomedicne at St. Petersburg State University.
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