The aptasensor-based point-of-care testing devices offer high sensitivity and specificity They are cost-effective, provide rapid detection, and are stable in an adverse environment making them suitable tools for on-site detection of cancer biomarkers in medical and clinical settings.
The present book emphasizes the target-specific design, functionalization, and synthesis of aptamers for the fabrication of aptamer-based biosensors which can be employed for cancer biomarkers detection. This book will provide the reader with a timely update on the recent advances in aptamers-based point-of-care biosensors for cancer diagnostics.
It will also demonstrate the advantages of aptamers such as low cost, ease of design, synthesis, and modification, hence can be employed as a good alternative to antibody-based biosensors. It will also shed light on nanostructured materials and their significance for the construction of point-of-care aptasensors. Furthermore, it will describe in detail the integration of a point-of-care aptasensors-based sensing platform integrated with a wireless platform (internet-of-medical things) for intelligent disease management.
Key Features:
- Highlights strategies for the synthesis of aptamers along with the design and fabrication of aptasensor-based point-of-care devices for early detection of cancer biomarkers and how these sensors can revolutionize the field of disease diagnostics.
- Details the technology of aptasensor-based point-of-care devices for disease diagnosis, with a specific focus on cancer diagnostic applications.
- Includes detailed information on the integration of aptasensor-based point-of-care technologies on the wireless platform internet-of-medical things for smart and intelligent disease management.
*Authors of the chapters of this book are well-known researchers in the field of cancer diagnostics and have incorporated specific case studies within their respective chapters.
Содержание
2. Point-of-Care Systems: Brief History to Recent Advances in the field of Cancer This chapter will include the fundamental applications and POC system information in a hospital with a brief history and its working principle for disease diagnosis mainly for cancer detection.
3. Aptasensors for Cancer Diagnostics: An Insight into Immobilisation Strategies This chapter will discuss the aptamer-based biosensor devices and aspects such as characterization of bio-recognition probes with their respective analytes, immobilization onto electrode surfaces, and development of anti-fouling surface chemistries. The special attention will be on different types of surface chemistry used for the development of simple, sensitive, and cost-effective aptasensors.
7. Detection of Cancer Biomarkers based on Electrochemical Aptasensor This chapter will describe recent advances made in the field of electrochemical aptasensors for the detection of cancer biomarkers such as specific genes, micro RNA, proteins, circulating tumor cells, cell lines, and exosomes or exosome-derived biomarkers.
Об авторе
Arpana Parihar is a DST Women Scientist-B at the CSIR-Advanced Materials and Processes Research Institute in Bhopal, India. She has over 8 years of research experience at various institutions such as RRCAT Indore, IIT Delhi, etc. particularly in the field of cancer theragnostic. Her current research interest includes the fabrication of biosensors for early diagnosis of cancer and infectious diseases. She also contributed significantly in the fields of, stem cell biology, tissue engineering, targeted therapy, and photodynamic therapy of cancer. She has published over 35 referred journal articles, 25 book chapters, and published 5 books.
Pushpesh Ranjan is currently working as a Ph.D. candidate at CSIR-Advanced Materials and Processes Research Institute (AMPRI) under the supervision of Dr. Raju Khan at the Industrial Waste Utilization, Nano and Biomaterials division. His current research is focused on the development of graphene oxide-ionic liquid-based nano biosensors, along with aptasensor-based point-of-care biosensors. He had over 5 years of research experience at CSIR-AMPRI Bhopal and IIT Indore. He has published over 19 referred journal articles and published >10 book chapters.
Raju Khan is a Senior Principal Scientist and Professor at CSIR-Advanced Materials and Processes Research Institute. His current research focuses on electrochemical biosensor point-of-care diagnostics, integrated with microfluidics for clinical applications. He has more than 15 years of R & D experience in CSIR and other academic institutions. He has also been a visiting scientist at the University of Texas at San Antonio. He has published more than 81 referred journal articles, which have attracted more than >3900 citations, published >25 book chapters, and been the editor of 10 books with Elsevier and Taylor & Francis.
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