Chemokines play an important role in recruiting inflammatory cells into tissues in response to infection and inflammation. They also play an important role in coordinating the movement of T-cells, B-cells and dentritic cells, necessary to generate an immune response (response to injury, allergens, antigens, invading microorganisms). They selectively attract leukocytes to inflammatory foci, inducing both cell migration and activation. They are involved in various diseases, like atherosclerosis, lung and skin inflammation, multiple sclerosis, or HIV.
Volume 1 of this two-volume set discusses the immunobiology of chemokines. It is divided into two parts: a) cellular targets in innate and adaptive immunity, and b) effector cell traffic-unrelated functions. Together with volume 2, which discusses the pathophysiology of chemokines, both volumes give a comprehensive overview of chemokine biology.
Содержание
Cellular targets in innate and adaptive immunity.- Traffic of T lymphocytes.- Lymphocyte homing to peripheral epithelial tissues.- Chemokine biology of NK cells and ?? T cells.- Dendritic cell traffic control by chemokines.- Chemokine receptor-mediated signal transduction.- Chemokines in leukocyte transendothelial migration.- Natural chemokine antagonism and synergism.- Effector cell traffic-unrelated functions.- Crosstalk between chemokine, opioid, and vanilloid receptors.- Antimicrobial and related activities of chemokines.- Virus-encoded chemokine modulators as novel anti-inflammatory reagents.- Chemokine receptors in tissue cells and angiogenesis.
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