This book constitutes the refereed proceedings of the 10th International Conference on Social, Cultural, and Behavioral Modeling & Prediction and Behavior Representation in Modeling and Simulation, SBP-BRi MS 2017, held in Washington, DC, USA, in July 2017.The 16 full papers and 27 short papers presented were carefully reviewed and selected from 79 submissions. Owing to its strong multi-disciplinary heritage, the papers represent a large range of disciplines including computer science, psychology, sociology, communication science, public health, bioinformatics, political science, and organizational science and use numerous types of computational methods such as machine learning, language technology, social network analysis and visualization, agent-based simulation, and statistics. They are organized in the following topical sections: behavioral and social sciences; cyber and intelligence applications; information, systems, and network sciences; and methodology.