Presenting the main concepts, this book leads students as well as advanced researchers from different disciplines to an understanding of current ideas in the complex field of comprehensive experimental investigation of biological objects, analysis of data, development of models, simulation, and hypothesis generation.
It provides readers with guidance on how a specific complex biological question may be tackled:
— How to formulate questions that can be answered
— Which experiments to perform
— Where to find information in databases and on the Internet
— What kinds of models are appropriate
— How to use simulation tools
— What can be learned from the comparison of experimental data and modeling results
— How to make testable predictions.
The authors demonstrate how mathematical concepts can illuminate the principles underlying biology at a genetic, molecular, cellular and even organism level, and how to use mathematical tools for analysis and prediction.
Содержание
Introduction
FIRST PART: GENERAL INTRODUCTION
Some Basic Principles
Biology in a Nut Shell
Mathematics in a Nut Shell
Experimental Techniques in a Nut Shell
SECOND PART: STANDARD MODELS AND APPROACHES IN SYSTEMS BIOLOGY
Metabolism
Signal Transduction
Special Biological Processes
Modeling of Gene Expression
Analysis of Gene Expression and Gene Network Reconstruction
Self-Organization and Evolution
Data Integration
What’s next?
THIRD PART: COMPUTER-BASED INFORMATION RETRIEVAL AND EXAMINATION
Databases and Tools on the Internet
Modelling Tools
Glossary
Об авторе
Edda Klipp (born 1965) studied biophysics at the Humboldt University Berlin, receiving her Ph D in theoretical biophysics. Since 2001 she has been head of the Kinetic Modeling Group. A member of the Yeast Systems Biology Network, her research interests include mathematical modeling of cellular systems, signal transduction, systems biology, and text mining.
Ralf Herwig (born 1967) studied mathematics and physics at the TU Berlin and Free University Berlin and wrote his Ph D on statistical clustering methods. He has been a group leader in bioinformatics since 2001 and works on several projects covering genomics, proteomics and systems biology.
Axel Kowald (born 1963) holds a Ph D in mathematical biology from the National Institute for Medical Research, London. He has worked at the University of Manchester, the Institute for Advanced Studies in Budapest, and the Humboldt University Berlin. His current research interests focus on the mathematical modeling of processes involved in the biology of aging and systems biology.
Christoph Wierling (born 1973) studied biology at the University of Münster, graduating in 1999. Currently he is working as a Ph D student on the modeling and simulation of biological systems and the development of computational tools for systems biology.
Hans Lehrach (born 1946) studied chemistry in Vienna and Braunschweig, receiving his Ph D from the Max Planck Institute for Experimental Medicine. He is director of the MPI for Molecular Genetics and was spokesman for the German Human Genome. Among others, he is a member of EMBO, on the project committee of the National Genome Research Network, and a fellow of the American Association for the Advancement of Science. His research interests focus on functional genomics, technology development and systems biology.
All the authors currently work at the Max Planck Institute for Molecular Genetics in Berlin.
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