The incorporation of Green Chemistry is a relatively new phenomenon in the drug discovery discipline, since the scale that chemists operate on in drug discovery is smaller than those of process and manufacturing chemistry. The necessary metrics are more difficult to obtain in drug discovery due to the diversity of reactions conducted. However, pharmaceutical companies are realizing that incorporation of green chemistry techniques at earlier stages of drug development can speed the development of a drug candidate.
Written by experts who have pioneered green chemistry efforts within their own institutions, this book provides a practical guide for both academic and industrial labs wanting to know where to start with introducing greener approaches for greatest return on investment.
The Editors have taken a comprehensive approach to the topic, covering the entire drug discovery process from molecule conception, through synthesis, formulation and toxicology with specific examples and case studies where green chemistry strategies have been implemented. Emerging techniques for performing greener drug discovery chemistry are addressed as well as cutting-edge topics like biologics discovery and continuous processing. Moreover, important surrounding issues such as intellectual property are included.
This book serves as a practical guide for both academic and industrial chemists who work across the breadth of the drug discovery discipline. Ultimately, readers will learn how to incorporate green chemistry strategies into their everyday workflow without slowing down their science.
Содержание
Introduction: The Five Ws of Pharmaceutical Green Chemistry; Barriers to Adopting Green Chemistry in Drug Discovery; Toward a Green Laboratory: One Reaction at a Time; Greener Solvent Usage for; Discovery Chemistry Analysis and Purification; Green Chemistry and High Throughput Screening; Continuous Processing in Drug Discovery; Applying Green Chemistry Principles in Biologics Drug Development; Recycling and Reuse in the Laboratory; The Need for a Green Electronic Lab Notebook; Toxicology for Chemical Safety and Sustainability; Environmental Regulations and the Green Chemist; Patent Protection and Green Chemistry Innovation; The Business Case for Green Chemistry in Drug Discovery
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