It is increasingly accepted that ‘institutions matter’ for economic organization and outcomes. The last decade has seen significant expansion in research examining how institutional contexts affect the nature and behaviour of firms, the operation of markets, and economic outcomes. Yet ‘institutions’ conceal a multitude of issues and perspectives. Much of this research has been comparative, and followed different models such as ‘varieties of capitalism’, ‘national business systems’, and ‘social systems of production’. This Handbook explores these issues, perspectives, and models, with the leading scholars in the area contributing chapters to provide a central reference point for academics, scholars, and students.