This book covers state-of-the-art topics covering evidences indicate that the gut microbiota can be harnessed for cancer prevention as well as to modulate the efficacy of chemotherapy and immunotherapy. This book includes: 1) characterization of the dysregulated microbiome in gastrointestinal cancers (Chapters 1-6); 2) the molecular mechanism of action of gut microbiota via microbial metabolites and direct interaction with host cancer or immune cells (Chapters 7-11); 3) key methodologies for studying the role of gut microbiota in cancers (Chapters 12-13); and 4) the potential application of gut microbes for the prevention and treatment of gastrointestinal cancers (Chapters 14-17).
The contributors are international experts in molecular and cellular biology, microbiology, metabolomics, bioinformatics and physician scientists to provide in-depth reviews of this subject. This book provides a rich resource of information on this important topic for graduate students, basic researchers and physicians.
Содержание
Introduction.- Gut microbiome in health and diseases.- Microbiome in colorectal cancer.- Microbiome in gastric cancer.- Microbiome in liver cancer.- Virus, fungi and archaea in gastrointestinal cancer.- Microbial metabolomics in gastrointestinal cancer.- Diet and gut microbiome in gastrointestinal cancer.- Diet and gut microbiome in fatty liver and its associated liver cancer.- Host-microbiome interaction in gastrointestinal cancer.- Gut microbiome and immune responses in gastrointestinal cancer.- Animal models in the study of microbiome in gastrointestinal cancer.- High-throughput sequencing data analyses for microbiome profiling.- Gut microbiota modulation: probiotics and prebiotics in gastrointestinal cancer.- Roles of gut microbiota in efficacy of anticancer treatment of gastrointestinal cancer.- Targeting gut microbiota to treat gastrointestinal cancer.
Об авторе
Editor Jun Yu is Choh-Ming Li Professor of Medicine and Therapeutics, Assistant Dean of Faculty of Medicine, Director of Institute of Digestive Disease, Director of State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong. She serves as Council Member of American Gastrointestinal Association (AGA) Microbiome & Microbial Therapy (MMT) (2018-2022) and Council Member of AGA Oncology (2017-2018); Vice-Chairman of Cancer and Gut Microbiome of Anti-Cancer Association China; Vice-Chairman of Digestive Committee of China Women Physicians Association; Vice-Chairman of HK Scientist Association; Deputy Editor of JGH, Associate Editor of Oncogene, Oncogenesis, Scientific Reports and Editor for Gut. H^10; 84 papers with IF > 20; ISI citation >26, 000, ISI h-index=84; Google Scholar h-index 106). She obtained 30 prestigious awards, including The National Natural Science Award 2020 and 2016; Top 10 Scientists in Global Gut Microbiome Research-Enthusiasm Gut Daily 2019; He Liang He Li Science and Technology Progress Award 2018; AGA Council Oncology Research Mentor Award 2017; The National Scientific and Technological Progress Award (Innovation Team) 2016; Croucher Senior Research Fellowship 2016; The National Science and Technology Progress Award 2012. Professor Yu is also the book editor of: Obesity, Fatty Liver and Liver Cancer, 2018. ISBN 978-981-10-8683-0. Springer.
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