The text of choice for instructors looking for an innovative, empirically based, and practice-oriented perspective on psychopathology is now in a revised and expanded second edition with 50% new material. The volume presents state-of-the-art information on the disorders most frequently seen in clinical practice, reviewing their etiology, DSM-5 classification, symptoms and clinical features, course, epidemiology, and associated comorbidities. With the goal of integrating science and practice, each chapter also provides substantive therapeutic guidelines derived from the research. Contributors identify underlying principles of change that clinicians can draw on to improve their effectiveness and offer critical guidance for assessment, case formulation, and evidence-based intervention. New to This Edition *Chapters on new topics—suicide, sleep difficulties, and sexual dysfunction. *New chapter on schizophrenia. *Updated throughout with current theory, findings, and clinical advances. *Increased attention to transdiagnostic concerns.