Naiara Rodríguez-Ezpeleta & Michael Hackenberg 
Bioinformatics for High Throughput Sequencing [PDF ebook] 

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Next generation sequencing is revolutionizing molecular biology. Owing to this new technology it is now possible to carry out a panoply of experiments at an unprecedented low cost and high speed. These go from sequencing whole genomes, transcriptomes and small non-coding RNAs to description of methylated regions, identification protein – DNA interaction sites and detection of structural variation. The generation of gigabases of sequence information for each of this huge bandwidth of applications in just a few days makes the development of bioinformatics applications for next generation sequencing data analysis as urgent as challenging.

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Содержание

Preface.- Introduction.- Overview of Sequencing Technology Platforms.- Applications of High Throughput Sequencing.- Computational Infrastructure and Basic Data Analysis for High-Throughput Sequencing.- Base-Calling for Bioinformaticians.- De Novo Short Read Assembly.- Short Read Mapping.- DNA-Protein Interaction Analysis (Ch IP-Seq).- Genome-wide Methylation Maps.- Differential Expression for RNA Sequencing (RNA-seq) Data: Mapping, Summarization, Statistical Analysis and Experimental Design.- Micro RNA Expression Profiling and Discovery.- Dissecting Splicing-Regulatory Network by Integrative Analysis of HITS-CLIP data.- Analysis of Metagenomics Data.- High Throughput Sequencing Data Analysis Software: Current State and Future Developments.- Index.

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язык английский ● Формат PDF ● страницы 255 ● ISBN 9781461407829 ● Размер файла 3.0 MB ● редактор Naiara Rodríguez-Ezpeleta & Michael Hackenberg ● издатель Springer New York ● город NY ● Страна US ● опубликованный 2011 ● Загружаемые 24 месяцы ● валюта EUR ● Код товара 2246690 ● Защита от копирования Социальный DRM

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