This book provides a collection of quantitative procedures in common use in we selected may be pharmacology and related disciplines. The procedures considered" core" since it is likely that all scientists who work with drugs will use these procedures at some time or another. By excluding very specialized topics, we managed to keep the size of the book small. thus making it handy reference-a handbook in the true sense. for quick Since many scientists and students now have access to electronic computers, of lower cost microcomputers is likely to increase com- and since the advent we also included a computer program for each puter availability even further, procedure. * The user need not know computer programming since all necessary information needed to run the programs is included here. The manual is divided into two parts. In the first, the pharmacologic basis for the calculation is briefly stated for each of the procedures (numbered 1 through 33). Then the appropriate equations (formulas) are given and an example of each calculation is provided. For each procedure, the discussion of theory and illustration of the calculation are brief and self-contained. With the tables in the Appendix and a pocket calculator, all of the calculations can be done without reference to any other source. It is recommended that the pro- cedure and sample calculation be read and understood before going to the automated "magic" of the computer program in Part II.