Seiji Nishino & Takeshi Sakurai 
The Orexin/Hypocretin System [PDF ebook] 
Physiology and Pathophysiology

History.- History and Overview of Orexin/Hypocretin Research.- Overview of the Orexin/Hypocretin Neuronal System.- Orexin and Orexin Receptors.- Orexin Projections and Localization of Orexin Receptors.- Neuronal Responses to Hypocretin/Orexin.- Afferent System of Orexin Neurons.- Assessment of Orexin/Hypocretin Functions in Tissue and Biological Fluids.- Hypocretin Measurements in the CSF, and Blood and Brain Tissue.- Hypocretin Receptor-Activated G Proteins Revealed by [35S]GTP?S Autoradiography.- Physiology.- Orexin System and Feeding Behavior.- Orexins and the Autonomic Nervous System.- Neuroendocrine Role of the Orexins (Hypocretins).- The Orexin/Hypocretin System and Stress and Emotion.- Physiology.- Hypocretin as a Wakefulness Regulatory Peptide.- Hypocretin/Orexin Tonus and Vigilance Control.- Hypocretin System and Aminergic and Cholinergic Systems in the Control of Vigilance.- Orexin and Hypothalamic Control of Sleep and Waking.- Hypocretin/Orexin and Motor Function.- Pathophysiology: Narcolepsy and Orexin/Hypocretin Deficiency.- Overview of Human Narcolepsy.- Canine Models of Narcolepsy.- Rodent Models of Human Narcolepsy-Cataplexy.- Pathophysiology: Narcolepsy and Orexin/Hypocretin Deficiency.- Hypocretin Deficiency in Human Narcolepsy.- Hypocretin Status in Neurological Disorders in Relation to Excessive Sleepiness and Cataplexy.- Hypocretin Measures in Psychiatric Disorders.- Neuroendocrinology of Human Narcolepsy.- Narcolepsy and Autoimmunity.- Pathophysiology: Narcolepsy and Orexin/Hypocretin Deficiency.- Pharmacology of Hypocretin/Orexin Peptides and Small Molecules.- Rescue of Narcoleptic Orexin Neuron-Ablated Mice by Ectopic Overexpression of Orexin Peptides.- Hypocretin/Orexin Replacement Therapy in Hypocretin/Orexin-Deficient Narcolepsy.