The first of its kind, this reference gives a comprehensive but concise introduction to epigenetics before covering the many interactions between hormone regulation and epigenetics at all levels. The contents are very well structured with no overlaps between chapters, and each one features supplementary material for use in presentations. Throughout, major emphasis is placed on pathological conditions, aiming at the many physiologists and developmental biologists who are familiar with the importance and mechanisms of hormone regulation but have a limited background in epigenetics.
Содержание
VOLUME 1
Eukaryotic Gene Expression by RNA Polymerase II
Epigenetic Code: Histone Modification, Gene Regulation, and Chromatin Dynamics
Histone Lysine Methylation, Demethylation, and Hormonal Gene Regulation
The Role of HATs and HDACs in Cell Physiology and Disease
The Short and Medium Stories of Noncoding RNAs: micro RNA and si RNA
Long Noncoding RNA (lnc RNA): Functions in Health and Disease
Histone Variants: Structure, Function, and Implication in Diseases
Genomic Imprinting in Mammals: Origin and Complexity of an Epigenetically Regulated Phenomenon
Centromere and Kinetochore: Essential Components for Chromosome Segregation
Nuclear Receptors and NR-coregulators: Mechanism of Action and Cell Signaling
VOLUME 2
Estrogen and Progesterone Receptor Signaling and Action
Gonadal Steroid Hormones and Brain Protection
Glucocorticoid Receptor-Mediated Signaling and Stress Metabolism
Targeting Androgen Signaling in Prostate Cancer
Role of Peroxisome Proliferator-Activated Receptors in Inflammation and Angiogenesis
RAR/RXR-Mediated Signaling
On the Trail of Thyroid Hormone Receptor Epigenetics
Insulin Signaling, Epigenetics, and Human Diseases
Endocrine Disruptors and Epigenetics
Endocrine Disruptors: Mechanism of Action and Impacts on Health and Environment
Об авторе
Subhrangsu S. Mandal is currently Associate Professor at the Department of Chemistry and Biochemistry, at The University of Texas at Arlington, Texas. He received his Ph D degree from the Indian Institute of Science, Bangalore, where he worked on chemical nucleases and cationic liposome-mediated gene delivery in the laboratory of Professor S. Bhattacharya. He joined the laboratory of Professor Linda J. Reha-Krantz as an Alberta Heritage Foundation for Medical Research (AHFMR) postdoctoral fellow in the University of Alberta, Canada. He later moved to the laboratory of Professor Danny Reinberg to research on eukaryotic transcription and gene regulation in human at the University of Medicine and Dentistry of New Jersey (UMDNJ)/Howard Hughes Medical Institute (HHMI). Prof. Mandal began his independent career at University of Texas at Arlington in 2005. Specifically he is investigating the function of Mixed Lineage Leukemia (MLL) family of histone methyl-transferases in gene activation, estrogen signalling, and tumorigenesis. In parallel, the Mandal laboratory is also developing novel gene targeted cancer therapy using mouse models.
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