This book, in Q&A format, addresses a wide range of clinically relevant topics and issues in Nonmalignant Hematology, or “Benign Hematology, ” with a view to offering a robust, engaging tool that will assist every hematologist and oncologist (pediatric and adult equally) in making decisions during day-to-day practice. The entire spectrum of the specialty is covered in more than 60 exceptional chapters written by acknowledged authorities in the field. The content is organized into well-designed broad sections on red cell disorders, platelet and coagulation disorders, coagulopathy in systemic diseases, thromboembolic disease and its management (including surgical), immune system and related disorders, hemostasis and thrombosis during pregnancy and in the newborn and elderly, and Transfusion Medicine. A key aspect of the book is the opportunity it affords expert physicians to express well-reasoned opinions regarding complex issues in Nonmalignant Hematology. Readers willfind that it provides a practical and immediately applicable compendium of answers to often complex and vexing questions. It will appeal to residents, fellows, house officers and more experienced practitioners around the globe.
Содержание
Part 1. Red Blood Cells.- Evaluation of anemia in children and adults.- Iron cycle and pathophysiology of iron homeostasis.- Porphyrias: Diagnosis and management.- Disorders of hemoglobin synthesis: Pathophysiology and diagnostic evaluation.- Management of thalassemias.- Allogeneic hematopoietic cell transplant in ß-thalassemia major.- Sickle cell disease: Prevention of complications.- Sickle cell disease: Management of complications.- Allogeneic hematopoietic cell transplant in sickle cell disease.- Anemia of inflammation.- Iron overload: Diagnosis, complications and management.- Megaloblastic and nutritional anemias.- Sideroblastic anemias: Diagnosis and management.- Primary autoimmune warm antibody hemolytic anemias.- Intrinsic hemolytic anemias: Pathophysiology, diagnosis and management.- Part 2. Platelets and Coagulation System.- Platelet disorders: Diagnostic tests and their interpretations.- Inherited platelet disorders: Diagnosis and management.- Acquired platelet disorders: Diagnosis and management.- Immune mediated thrombocytopenia.- Coagulation cascade and fibrinolysis pathway: Assessment in the laboratory.- Abnormalities in fibrinolysis pathway and clinical implications.- Congenital disorders of fibrinogen: Clinical presentations, diagnosis and management.- Hemophilias A and B: Diagnosis and management.- Coagulation factor inhibitors: Diagnosis and management.- Rare coagulation factor deficiencies: Diagnosis and management.- von Willebrand disease: Differential diagnosis and diagnostic approach to specific subtypes.- von Willebrand disease: Prevention of complications and management of the disease.- Antifibrolytics: Indications and precautions.- Gene therapy for bleeding disorders.- Part 3. Coagulopathy in Systemic Diseases.- Disseminated intravascular coagulopathy.- Coagulopathy in critically ill subjects.- Trauma-associated coagulopathy.- Coagulation related issues in malignant hematology: Diagnosis and management.- Unmet clinicalneeds of antithrombotic treatment in BCR/ABL negative myeloproliferative neoplasms.- Bleeding and thrombosis in a cancer patient.- Management of surgical patient with thrombotic and bleeding diathesis.- Part 3. Thrombosis and Therapeutics.- Prevention and treatment of arterial thromboembolism.- mes New Roman’, ‘serif»>Prevention of venous thromboembolism.- Diagnostic, prognostic and therapeutic challenges in venous thromboembolisim.- Complications of venous thromboembolic disease.- Hereditary thrombophilias: Pathophysiology, timing of testing and familiar testing.- Anti-phospholipid antibodies and syndrome: Complexities in diagnosis and management.- Unidentifiable thrombophilias.- Anticoagulation drugs: Indications, therapeutic monitoring and antidotes.- Heparin induced thrombocytopenia: Diagnosis and management.- Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome.- Surgical treatment of thromboembolic disease.- Part 4. Immune System and Related Disorders.- Nonmalignant leukocyte disorders.- Primary immunodeficiency disorders: Diagnosis and management.- Disorders of phagocytic function: Diagnosis and treatment.- Inherited bone marrow failure syndromes.- Hemophagocytic lymphohistiocytosis: Diagnosis and management challenges.- Lysosomal storage disorders: Hematology perspective.- Cryoglobulins and cryoglobulinemia.- Part 5. Hemostasis and Thrombosis in Pregnancy, Newborn and Elderly.- Reproductive issues in women with bleeding and thrombotic disorders.- Pregnancy in subjects with hemoglobinopathies: Precautions and management.- Neonatal thrombosis and coagulopathies.- Bleeding and thrombosis in elderly.- Part 6. Transfusion Medicine.- Transfusion support: Indications, efficacy and complications.- Human blood antigens and antibodies: Diagnostic and therapeutic implications.- Therapeutic apheresis in hematologic disorders: When and Why?
Об авторе
Syed Abutalib is Assistant Director of Hematology and Blood and Marrow Hematopoietic Cell Transplant Program. Dr. Abutalib earned his medical degree from Dow Medical College in Karachi, Pakistan and subsequently completed a residency in Internal Medicine at Cook County Hospital and a Fellowship in Hematology/Oncology at the University of Illinois at Chicago. During his Fellowship he participated in Leukemia Research at Northwestern Hospital & University of Chicago. Board certified in Internal Medicine, Medical Oncology and Hematology, Dr. Abutalib specializes in benign hematology, malignant hematology and hematopoietic blood and marrow cell transplant. Dr. Abutalib has been published in several peer-reviewed journals, including the American Journal of Hematology, Current Pharmaceutical Biotechnology, and the American Journal of Clinical Pathology and has written chapters for medical textbooks, including Acute Leukemias (2008), Evidence-Based Hematology(2008), Expert Hematology & Oncology Essentials (2014) and Cancer Consult-Expertise for Clinical Practice (2014), Essential Oncology (2015). Dr. Abutalib is the editor of several books including, Cancer Consult-Expertise for Clinical Practice published on behalf of Blackwell Wiley Health Sciences. He is on the editorial board for Clinical Oncology News and THE ASCO POST magazine and contributes regularly in the column ‘ How I Manage..’ and “Expert Hematology Review”, respectively. Besides his Patients he hold Medical Education dear to his heart.
Jean M. Connors is an Assistant Professor of Medicine at Harvard Medical School. Dr Connors received her medical degree from Johns Hopkins University School of Medicine in Baltimore, Maryland. She completed residency in Internal Medicineat Beth Israel Hospital, Boston, Massachusetts, and fellowships in both Hematology/Oncology and Transfusion Medicine at Brigham and Women’s Hospital, Boston. Dr Connors cares for patients with inherited and acquired thrombotic and coagulation disorders. As Medical Director of the Brigham and Women’s Hospital and Dana Farber Cancer Institute Anticoagulation Management Service, Dr Connors oversees anticoagulation practices in outpatient clinical settings. She is also the Medical Director of the Hemostatic Antithrombotic Stewardship program, a multi-disciplinary care delivery program, to ensure judicious and optimal use of anticoagulants and clotting factors across all BWH inpatient services. She has participated in a variety of types of clinical trials focusing on anticoagulation including investigator initiated, served on scientific advisory boards for a number of companies, teaches extensively at many levels including peers in CME courses as well as fellows and residents, and has written numerous reviews and chapters in the area of thrombosis-hemostasis.
Margaret Ragni is a Professor of Medicine and Clinical Translational Science at the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. She received her MD from the University of Pittsburgh School of Medicine and a Master of Public Health from the University of Pittsburgh School of Public Health. She completed her residency and fellowship in hematology/oncology at the University of Pittsburgh Medical Center in Pittsburgh, where she joined the faculty in 1983. Dr. Ragni’s research interests are in congenital and acquired disorders of hemostasis and thrombosis, and, in, particular in novel therapeutics for patients with hemophilia with and without inhibitors. She serves on the Medical and Scientific Advisory Committee of the National Hemophilia Foundation (NHF), the FDA Blood Products Advisory Committee, the Scientific Committee on Hemostasis of the American Society of Hematology, and on the Medical Advisory Board for the Foundation for Women and Girls with Blood Disorders (FWGBD). She also served as Co-Chair for the 2014 ASH Annual Meeting; as Co-Chair of the Research Committee of the Hemostasis & Thrombosis Research Society, and is a member of the Research Committee of the American Thrombosis & Hemostasis Network. She is past member of the Hemostasis Thrombosis Study Section of the NHLBI, and Co-Chair of the Bleeding Disorders Subcommittee of the NHLBI State of the Science Symposium. She serves on Scientific Advisory Boards for Alnylam, Baxalta, Biogen, and Biomarin. She has conducted numerous clinical trials, observational studies, retrospective data base analyses, cost-effectiveness analyses, and investigator-initiated new drug trials in hemophilia and von Willebrand disease. She is the medical director of the Hemophilia Center of Western PA, providing care for patients with bleeding and clotting disorders, teach and mentor medical students, residents, fellows, and young faculty.
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