This book reviews the latest research on the molecules and mechanisms of marine host stress responses to viral infections and tumorigenesis. It offers an overview of the state of the art in the field as well as future directions.
Metabolism disorder is a characteristic of tumorigenesis. Since viruses complete their life cycle in host cells, such infections cause metabolic disorders in the host. As such, the mechanisms of virus pathogenesis and tumor progression are similar or even identical. In essence, the role of antiviral molecules is to maintain the metabolic homeostasis of infected host cells, and the antiviral molecules induced by virus infection may play an important role in antitumor pathways, resulting in cancer cell death or restoring the disordered metabolism of cancer cells. The molecules generated during host stress responses to viruses can also contribute to the antitumor mechanisms in humans. However, the relationship between host stress responses to virus infection and tumorigenesis has not been extensively explored.
In recent years, studies have shown that marine host stress responses to viral invasion can be good models for exploring human antitumor mechanisms. Stimulating further research in the field, this book offers graduate students and researchers with comprehensive insights into host stress responses to viral invasion and tumor progression. It is also a valuable resource for those working in the pharmaceutical industry interested in drug discovery based on molecules derived from host stress responses to viral infection.
Содержание
Overview of virus infection and tumorigenesis.- Marine viruses.- Marine invertebrate stress responses to virus infection.- The roles of micro RNAs in antiviral immunity of marine invertebrates.- Marine microbe stress responses to bacteriophage infection.- Roles of microbial metabolites in bacteriophage-microbe interactions.- Tumorigenesis and metabolism disorder.- Effects of micro RNAs from marine invertebrate stress responses to virus infection on tumorigenesis.- Anti-tumor activities of secondary metabolites from marine microbe stress responses to virus infection.
Об авторе
Dr. Xiaobo Zhang is a Professor from the College of Life Sciences, Zhejiang University. He was selected for the “National Natural Science Foundation of China for Distinguished Young Scholars” in 2005 and “National New Century Millions of Talents Program” in 2006. He is a standing committee member for the Marine Biotechnology branch of the Chinese Society for Oceanography and a committee member for the Marine Microbiology branch of the Chinese Society for Microbiology. Prof. Zhang’s research focuses on mechanisms of marine hosts’ response to virus infection and tumorigenesis. He has published more than 110 research articles in these fields.
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