Asymmetric C-H direct functionalization reactions are one of the most active and fascinating areas of research in organic chemistry due to their significance in the construction of molecular complexity without pre-activation, and the step economy and atom economy features in potential synthetic application. Distinguishing the reactivity among numerous C–H bonds in one single molecule represents one of the most challenging issues in organic synthesis and requires precise reaction design. As such, this field is now receiving increasing attention from researchers.
This book provides the first comprehensive review of this field, summarizing the origin, mechanism, scope and applications of the asymmetric C-H bond functionalization reaction. It covers organocatalytic reactions and transition-metal-catalyzed reactions, as well as asymmetric C-H functionalization reactions not described in other books.
Written by a leading expert in this field, the book is ideal for postgraduates and researchers working in organic synthesis, catalysis, and organometallic chemistry.
Table of Content
Asymmetric C–H Bond Insertion Reactions; Asymmetric Cross-dehydrogenative Coupling (CDC) Reactions; Asymmetric Oxidative Biaryl Coupling Reactions; Asymmetric [1, 5]-Hydride Transfer Reactions; Asymmetric Functionalization of C–H Bonds via a Transient M–C Species; Asymmetric Friedel–Crafts Reactions; NHC-catalyzed Asymmetric Functionalization of Aldehyde C–H Bonds; Asymmetric Hydroacylation Reactions; Asymmetric Hydrovinylation Reactions; Index.
About the author
Shu-Li You is Professor of Chemistry at the Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China. His research interests mainly focus on enantioselective direct C-H bond functionalization and catalytic asymmetric dearomatization (CADA) reaction. Professor You has received numerous awards and is a member of the Advisory Board for several journals, including
Chemical Society Reviews,
Chemical Communications,
Organic & Biomolecular Chemistry, and
ACS Catalysis.
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