The last twenty years have seen significant strides in radiosurgical care, much of which was made possible by the Cyber Knife technology. With an ever-increasing number of Cyber Knife stereotactic radiosurgery units installed across the globe and thousands of physicians using them on a daily basis, the field of Cyber Knife technology has grown rapidly. As minimally invasive, frameless, stereotactic radiosurgery gains popularity, this formal reference will soon become indispensable in understanding the application of Cyber Knife SRS. This text provides a comprehensive reference for the treatment of various pathologies; it is meant to serve as manual for both new and experienced clinicians alike. Some of the most experienced Cyber Knife users from around the world have contributed their knowledge and experience using Cyber Knife. Each chapter covers a different disease process, focusing on various spinal pathologies. The content specifically highlights how the current use of Cyber Knife relates to other radiosurgical modalities and treatment options by discussing advantages, disadvantages, dosing, complications, and efficacy. We hope that this text will serve as a reference, guiding clinicians in the application of an emerging technology.