Advances in Chemotherapy, Volume 1 presents the significant progress both in theoretical and experimental aspects in the various disciplines comprising chemotherapy field. This volume is divided into nine chapters, and begins with an introduction to the historical developments in chemotherapy. The subsequent chapters deal with the nature, use, and limitations of drug predictive systems and the experimental results concerning the trypanocidal activity of phenanthridine and aminoquinaldine. These topics are followed by discussions on chemoprophylaxis and chemotherapy of tumor viruses, the antitumor activity of alkaloidal substances from Vinca rosea plant, and the correlation between inhibitory activity in mammalian cell assays and experimental antitumor activity. A chapter considers the interplay of immune mechanisms and drugs in the clinical and veterinary aspects of antiparasitic chemotherapy. The final chapters look into some of the pharmacological, therapeutic, and biochemical bases for the combined actions of drugs, with special emphasis on the combination chemotherapy of cancer and factors which may influence its effectiveness. These chapters also describe the concept of using inhibitors in chemotherapy. This book will prove useful to oncologists and other workers in the medical profession with background of chemotherapy.
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