This book is a comprehensive volume dedicated to dermal absorption and decontamination. Given risks including chemical warfare and accidents with toxic industrial chemicals, studies involving dermal absorption and decontamination are of the utmost importance. Each chapter consists of a systematic review on an important dermal absorption and/or decontamination topic. Chapters address key issues such as the general acceptance of water/ soap and water as the gold standard of dermal decontamination despite the fact that it commonly provides incomplete decontamination and may even result in a “wash-in effect” (an increased penetration of contaminant). Decontamination with other substances (e.g. RSDL) is explored, and factors that affect dermal penetration (e.g. anatomical variation) are summarized. All systematic reviews are comprehensive and up-to-date.
Dermal Absorption and Decontamination will be useful for many fields and disciplines. Firstly, information on dermal decontamination may be used by governments for military and national defense purposes in the event of chemical warfare. Additionally, this information would be of use to many production companies, whose employees are at risk of an accident with toxic industrial chemicals. Topics covered in the book will also be of use to pharmaceutical companies, especially those exploring transdermal delivery of drugs and is of great relevance to those in the medical field, particularly dermatologists.
Innehållsförteckning
Skin Decontamination with Water: Evidence from In Vivo Human Studies.- Towards a harmonized protocol for in vitro human skin decontamination efficacy.- In Vitro Human Skin Decontamination with Water: Chemical Warfare Agents or Simulants.- In Vitro Human Skin Decontamination with Water: Occupational Contaminants.- Skin Decontamination with Water: Evidence from In Vivo Animal Models.- Skin Decontamination with Water: Evidence from In Vitro Animal Models.- Dry Decontamination with Readily Available Products.- A Review of Reactive Skin Decontamination Lotion Efficacy.- Aqueous suspensions of Fuller’s earth potentiate the adsorption capacities of Paraoxon and improve skin decontamination properties.- Development of a next generation military skin decontaminant: Initial efficacy studies of Zirconium Hydroxide.- Findings from the PHOENIX project: ‘Protocols for Hair and the Optimisation of Existing and Novel decontamination Interventions through experimentation.- Twenty clinically pertinent factors/ observations for percutaneous absorption in humans.- Lateral Spread and Percutaneous Penetration: An Overview.- Regional Variation in Percutaneous Absorption: Evidence from In Vitro Human Models.- Experimental Variability in TEWL Data.- Relationships Between Skin of Color and the TEWL Barrier.
Om författaren
Aileen M Feschuk
Faculty of Medicine, Memorial University of Newfoundland, St. John’s, NL, Canada
Rebecca M Law, Pharm D
School of Pharmacy, Memorial University of Newfoundland
Faculty of Medicine, Memorial University of Newfoundland
St. John’s, NL, Canada
Howard I Maibach, MD
Department of Dermatology, University of California San Francisco, San Francisco, CA, USA
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