During the past ten years, several theories have been proposed on the origin of the diversity of antibodies. This book presents a critical study of these theories in a detailed treatment of immunological problems from the point of view of molecular Introduction to Genetics: A Molecular Approach. The text in this book uses a new and simplifying approach to this long-standing controversy. By a comprehensive computerized analysis of antibody amino acid sequences (particularly the myeloma proteins), the authors trace their evolution and match their results against the expectations of the various theories of diversity. They discuss at length the other types of evidence as well. This book also deals with the clonal specialization of cells to produce a single antibody, and the relationship of this specialization to the somatic joining of antibody half-genes, which is one of the immune system’s most important peculiarities. Introductory material is provided to make this work understandable to molecular geneticists not versed in immunology and to immunologists not versed in molecular Introduction to Genetics: A Molecular Approach. This is a timely book offering a succinct and coherent summary of the various lines of evidence in a confused and controversial field.
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