Hypoxia is an important phenomenon possessing a significant correlation with tumour progression, treatment results and the overall disease prognosis. Tumor oxygenation state leads to a series of genomic changes, enabling tumor cells survival or overcoming the oxygen deficient environment conditions. Tumor tissue growth requires a sufficient oxygen and nutrients supply. Tumor cell responses to hypoxic stress include adaptive proteomic changes allowing the cells to overcome nutritive deprivation or to escape their hostile environment by proliferation, invasion, or metastatic spread. Tumor cell proliferation requires rapid synthesis of macromolecules including lipids, proteins, and nucleotides. This book will supply information regarding this pattern in brain cancer.