This book constitutes the proceedings of the 15th International Conference on Social, Cultural, and Behavioral Modeling, SBP-BRi MS 2022, which was in Pittsburgh, PA, USA in September 2022.The 25 full papers presented in this volume were carefully reviewed and selected from 50 submissions. The papers were organized in topical sections as follows: computer science, psychology, sociology, communication science, public health, bioinformatics, political science, and organizational science. Numerous types of computational methods are used include, but not limited to, machine learning, language technology, social network analysis and visualization, agent-based simulation, and statistics.