A vital resource on blood and bone marrow cell morphology in
laboratory animal medicine. This fully revised new edition is an
essential reference for clinical pathologists in diagnostic
laboratories, and medical or veterinary research. The atlas
contains over 400 color images of cells from the peripheral blood
and bone marrow from a variety of animals encountered in laboratory
animal medicine, in health and disease.
Key features:
* New chapter on flow cytometry and its application in terms of
routine analyses as a means of identifying abnormalities in cell
marker expression, which is of particular relevance for
pre-clinical safety assessment
* Covers the most recent developments in laboratory animal
hematology, including parameters measured by the latest generation
of analyzers
* Coverage of a wide range of laboratory animal species, as well
as those used in clinical veterinary trials
* Photomicrographs present normal and abnormal blood cells from a
variety of hematological conditions along with descriptive
text
Innehållsförteckning
Foreword vii
Introduction ix
Dedication xi
Acknowledgments xiii
1 Rodents 1
Mouse 1
Introduction 1
Blood picture 1
Typical ranges (Siemens Advia 120) 2
Hamster 15
Introduction 15
Blood picture 15
Guinea Pig 17
Introduction 17
Blood picture 17
Rat – Sprague Dawley (SD)/Han Wistar (HW) 18
Introduction 18
Blood picture 18
Typical ranges (Siemens Advia 120) 19
References 36
2 Rabbit 37
Introduction 37
Blood picture 37
References 39
4 Dog 45
Introduction 45
Blood picture 45
Typical ranges (Siemens Advia 120) 46
References 64
5 Monkey 65
Introduction 65
Blood picture 65
Marmoset 66
Cynomolgus 71
Introduction 71
Blood picture 71
Typical ranges (Siemens Advia 120) 72
Baboon 84
Rhesus Monkey 86
References 87
6 Other species 89
Pig 89
Introduction 89
Blood picture 89
Horse 91
Introduction 91
Blood picture 91
Goat and Sheep 94
Assorted Other Species 96
References 103
3 Cat 41
Introduction 41
Blood picture 41
References 44
7 Blood collection procedures 105
Common bleeding sites 105
Anticoagulants 105
Staining 105
8 Artifacts 107
Collection artifacts 107
Sample transport and storage 109
Anticoagulant 110
Storage artifacts 111
Blood smear preparation 113
Stain precipitate 113
References 114
9 Bone marrow 115
Introduction 115
Review of marrow sampling techniques 115
Recommended methods for marrow sampling 116
Preparation and staining of smears 118
Evaluation 119
Interpretation 119
References 120
10 Comparative applications in flow cytometry 121
Application of flow cytometry in comparative hematology 122
References 132
Index 135
Om författaren
Clifford Smith is Chief Laboratory Scientist in the
Haematology Department, and Head of Logistics, Clinical Pathology
Services, at Covance Laboratories in Harrogate, UK.
Alfred Jarecki is Principal Research Scientist with
Sanofi-Aventis at the Alnwick Research Centre, UK.
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