In a globalizing, knowledge-based economy, innovation and creative capacity lead to economic prosperity. Starting in 2006, the Innovation Systems Research Network began a six year-long study on how city-regions in Canada were surviving and thriving in a globalized world. That study resulted in the “Innovation, Creativity, and Governance in Canadian City-Regions” series, which examines the impact of innovation, talent, and institutions on sixteen city-regions across Canada. This volume explores how the social dynamics that influence innovation and knowledge flows in Canadian city-regions contribute to transformation and long-term growth.With case studies examining cities of all sizes, from Toronto to Moncton, Innovating in Urban Economies analyzes the impact of size, location, and the regional economy on innovation and knowledge in Canada’s cities.