The past decade has seen mounting global concern regarding viral
outbreaks such as SARS, avian influenza and West Nile virus. In
2004 and 2005, reports of bird-to-human, and possible
human-to-human, transmissions of the H5N1 influenza viruses raised
fears that these viruses could cause a pandemic on the scale of the
Spanish flu pandemic of 1918. Previous to this, a novel
coronavirus had been identified as the aetiological agent of the
severe acute respiratory syndrome (SARS), a new respiratory viral
disease that emerged at the end of 2002 and caused profound
disturbances in over 30 countries worldwide in 2003. It is not
known whether the SARS coronavirus will re-emerge, especially since
its origins and potential reservoir(s) are unresolved. However,
these outbreaks have shown that these viruses can emerge in any
part of the world at any time.
This book critically evaluates the latest scientific evidence on
novel or re-emerging viral diseases and brings together
contributions from world experts on this topic, explaining best
practice in their area, and discussing lessons learned and how best
to collaborate to prevent and control future outbreaks.
Topics covered include:
* the latest advances in virology, particularly in the area of
epidemiology
* diagnostics
* animal models for viral infection
* antiviral and vaccine development
Novel and Re-emerging Respiratory Viral Diseases offers a
comprehensive and interdisciplinary account of all aspects of the
topic, from basic molecular biology to public health issues, and is
therefore essential reading for virologists, infectious disease
specialists, public health managers, researchers and
epidemiologists, as well as those working in vaccine development,
pharmaceutical medicine and drug discovery
Innehållsförteckning
Symposium on Novel and re-emerging respiratory viral diseases,
held at the Institute of Molecular and Cell Biolog y, Singapore,
23-25 April 2007.
Editors: Gregory Bock (Organizer) and Jamie Goode.
This meeting was based on a proposal made by Yee-Joo Tan and
Wanjin Hong.
Robert G. Webster Chair’s introduction.
Larry J. Anderson and Suxiang Tong Identification
and characterization of novel viruses.
Discussion.
Edward C. Holmes The evolution of viral emergence.
Discussion.
Derek J. Smith, Jan C. de Jong, Alan S. Lapedes, Terry C.
Jones, Colin A. Russell, Theo M. Bestebroer, Guus F. Rimmelzwaan,
Albert D. M. E. Osterhaus and Ron A. M. Fouchier
Antigenic artography of human and swine influenza A (H3N2)
viruses.
Discussion.
Gabriele Neumann and Yoshihiro Kawaoka Infl uenza
pandemics and control.
Discussion.
J. J. Skehel, S. Wharton, L. Calder and D. Stevens
On the activation of membrane fusion by influenza
haemagglutinin.
Discussion.
Yee Sin Leo Singapore SARS experience and preparation for
future outbreak.
Discussion.
Yee-Joo Tan SARS lessons for a young virology laboratory
in Singapore.
Discussion.
Ih-Jen Su How the SARS experience has helped preparations
for future outbreaks: the Taiwan experience, with emphasis on the
successful control of institutional outbreak of influenza in
2003/2004 using a stockpile of antivirals.
Discussion.
General discussion I.
Yuelong Shu, Yu Lan, Leying Wen, Ye Zhang, Jie Dong, Xinsheng
Zhao, Dayan Wang, Lihong Yao, Xiyan Li, Wei Wang, Xiuping Wang, Qi
Wang, Shumin Duan, Jingjing Huang, Lei Yang, Hongjie Yu, Yuanji
Guo, Weizhong Yang, Xiyan Xu, Nancy J. Cox, Xiaoping Dong, Yu
Wang and Dexin Li Genetic and antigenic characterization
of avian influenza A (H5N1) viruses isolated from humans in
Mainland China.
Discussion.
J. S. M. Peiris and Y. Guan Emerging infectious
diseases and the animal-human interface.
Discussion.
Erich Hoffmann, Hui-Ling Yen, Rachelle Salomon, Neziha
Yilmaz and Robert G. Webster Transmission and
pathogenicity of H5N1 influenza viruses.
Discussion.
John M. Wood Development of vaccine for a future
influenza pandemic.
Discussion.
Final discussion.
Index of contributors.
Subject index.
Om författaren
The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.
Chairman: Robert G Webster, St. Jude Children’s?Research Hospital, Memphis, USA.
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