While the sequence of the human genome sequence has hit the
headlines, extensive exploitation of this for practical
applications is still to come. Genomic and post-genomic
technologies applied to viral and bacterial pathogens, which are
almost equally important from a scientific perspective, have the
potential to be translated into useful products and processes much
more rapidly.
Genomics, Proteomics and Vaccines introduces the history of
vaccinology and discusses how vaccines are expected to evolve in
the future. It describes the relevant technologies, including
genome sequencing and analysis, DNA microarrays, 2D electrophoresis
and 2D chromatography, mass spectrometry and high-throughput
protein expression and purification. The book also features
examples of the exploitation of genomics and post-genomics in
vaccine discovery, and contains useful descriptions of the biology
and pathogenesis of clinically important bacterial pathogens.
This book should be of interest to all those working in vaccine
discovery and development in pharmaceutical and biotechnology
companies as well as in academic institutions
Innehållsförteckning
Preface.
List of Contributors.
PART 1: INTRODUCTION.
1. Vaccination: Past, Present and Future (Maria Lattanzi and
Rino Rappuoli).
2. Bioinformatics, DNA Microarrays and Proteomics in Vaccine
Discovery: Competing or Complementary Technologies? (Guido
Grandi).
PART 2: TECHNOLOGIES.
3. Genome Sequencing and Analysis (Hervé Tettelin and
Tamara Feldblyum).
4. Understanding DNA Microarrays: Sources and Magnitudes of
Variances in DNA Microarray Data Sets (She-pin Hung, G. Wesley
Hatfield, Suman Sundaresh and Pierre F. Baldi).
5. The proteome, Anno Domini Two Zero Zero Three (Pier
Giorgio Righetti, Mahmoud Hamdan, Frederic Reymond and Joël S.
Rossier).
6. Mass Spectrometry in Proteomics (Pierre-Alain Binz).
7. High Throughput Cloning, Expression and Purification
Technologies (Andreas Kreusch and Scott A. Lesley).
PART 3: APPLICATIONS.
8. Meningococcus B: from Genome to Vaccine (Davide Serruto, Rino
Rappuoli and Mariagrazia Pizza).
9. Vaccines Against Pathogenic Streptococci (John L. Telford,
Immaculada Margarit y Ros, Domenico Maione, Vega Masignani,
Hervé Tettelin, Giuliano Bensi and Guido Grandi).
10. Identification of the ’Antigenome’-a Novel Tools for
Design and Development of Subunit Vaccines Against Bacterial
Pathogens (Eszter Nagy, Tamás Henics, Alexander von Gabain and
Andreas Meinke).
11. Searching the Chlamydia Genomes for New Vaccine Candidates
(Giulio Ratti, Oretta Finco and Guido Grandi).
12. Proteomics and Anti-Chlamydia Vaccine Discovery (Gunna
Christiansen, Svend Birkelund, Brian B. Vandahl and Allan C
Shaw).
13. Proteome Analysis of Other Membrane and Extracelular
Proteins from Pseudomonas aeruginosa for vaccine Discovery
(Stuart J. Cordwell and Amanda S. Nouwens).
Index.
Om författaren
Guido Grandi is the editor of Genomics, Proteomics and Vaccines, published by Wiley.
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