This volume constitutes the proceedings of the 6th IFIP WG 8.1 Conference on the Practice of Enterprise Modeling held in November 2013 in Riga, Latvia. The focus of the Po EM conference series is on advances in the practice of enterprise modeling through a forum for sharing knowledge and experiences between the academic community and practitioners from industry and the public sector.The 19 papers accepted were carefully reviewed and selected from 80 submissions. They reflect different topics of enterprise modeling including quality of models, change management and transformation, approaches and tools for agility and flexibility, enterprise modeling and business processes, enterprise modeling and information systems and enterprise modeling cases. Additionally, one of the two keynotes is also included in this volume.