This classroom resource addresses the instructional challenges faced by fourth to eighth grade teachers and provides research-based tools needed to improve students’ reading comprehension. These classroom-tested interventions can be used with struggling readers in 5-, 10 to 15-, and 30 to 40-minute settings. Key features of this professional development resource include: responsive teaching and differentiation; the four kinds of interventions that can support students’ reading; intervention tools and strategies for teachers and students; the use of focus standards to discuss key reading strategies (inferring, finding main ideas and themes, and using context to determine a word’s meaning); and getting students to write about their reading.