This volume includes eight chapters that provide updates on recent advances in health and disease research. Chapter One reviews the clinical uses of mitomycin C in the eye and its complications. Chapter Two reviews the current knowledge and understanding on the regulatory mechanisms and pathophysiology of urinary stone disease. Chapter Three discusses how the Association of Southeast Asian Nations deals with the COVID-19 pandemic and how it adapts its disaster management mechanisms with its existing bureaucracy. Chapter Four describes the applications of computed tomography scans in the assessment of craniofacial morphology. Chapter Five discusses the work done using scanning electron microscopy-energy dispersive X-ray spectroscopy to describe the structural and compositional investigations in kidney stones and its evolution over the decades. Chapter Six deals with the complex host-microbe interactions associated with the pathogenesis of post-COVID mucormycosis and its management in the primary and revision scenario. Chapter Seven highlights the potential role of Vitamin D and Vitamin D receptor gene polymorphism in the prognosis of kidney stone formation through extensive secondary data. Finally, Chapter Eight examines the utility of village folklore medicines for management of stress and other applications.