This reference book originates from the interdisciplinary research cooperation between academia and industry. In three distinct parts, latest results from basic research on stable enzymes are explained and brought into context with possible industrial applications. Downstream processing technology as well as biocatalytic and biotechnological production processes from global players display the enormous potential of biocatalysts. Application of ’extreme’ reaction conditions (i.e. unconventional, such as high temperature, pressure, and p H value) – biocatalysts are normally used within a well defined process window – leads to novel synthetic effects. Both novel enzyme systems and the synthetic routes in which they can be applied are made accessible to the reader. In addition, the complementary innovative process technology under unconventional conditions is highlighted by latest examples from biotech industry.
Innehållsförteckning
FERMENTATION & DOWNSTREAM PROCESSING TECHNOLOGIES
Process development tools for fermentations under extreme conditions (Pro Tool)
Development of fully automated integrated bioprocesses in an industrial compatible pilot plant for the production of heterologous enzymes in yeast
Application of tailor made porous adsorbents in enzymatic processes
In-situ video microscopy for investigation and optimization of protein crystallization in downstream processing
Innovative plasma technology for enzyme immobilization
New membrane adsorber technology for downstream processing in enzyme production
BIOCATALYSIS & BIOTECHNOLOGICAL PRODUCTION PROZESSES
Biocatalysis in high viscous media
COMPASITES: Computer assisted analysis of active centers in proteins
Kongeneric lipases with improved catalytic activity and substrate accessibility
Biocatalytic exploitation of flavonoids
New Bacillus expression systems
First Se Sa M-mutagenesis kit for evolutionary biocatalyst design
Development of a probiotic preserving agent for industrial applications
Development of a biotechnological production process for non-natural cyclopeptides – Bio PEP
Biocatalytic exploitation of flavor enhancing aroma compounds
STABLE ENZYMES
Enzymatic oxidation systems food and technical applications
Preparation of new perhydrolases: Simultaneous enhancement of specific activity of perhydrolases and reduction of hydrolysis activity
Nucleases and proteases exhibiting improved properties for molecular preanalytics
Stable enzymes for the conversion of high value and uncommon substrates
Om författaren
Dr. Lutz Hilterhaus carried out his studies of chemistry at the University Münster before moving to Hamburg. Having obtained his Ph D from the Hamburg University of Technology (TUHH) in the working group of Prof. Liese in 2008, he spent one year with Prof. Bornscheuer at the University Greifswald before taking up the possibility to start as a Junior Group Leader at the Institute of Technical Biocatalysis at the TUHH. Dr. Lutz Hilterhaus finalized his habilitation in 2016 and has authored over 30 scientific publications and has received the ’Karl-Heinz-Ditze Preis für besondere Leistungen in den Ingenieurwissenschaften’ in 2008.
Dr. Andreas Liese is Professor at the Hamburg University of Technology, where he is head of the Institute of Technical Biocatalysis. He studied chemistry at the University of Bonn, Germany, and carried out his doctoral research at the Research Center Jülich, Germany. From 1998 to 2003 he was head of the Enzyme Group within the Institute of Biotechnology II (Prof. Dr. C. Wandrey), Research Center Jülich. During a sabbatical in 2000 at Pfizer Global Research & Development, San Diego, USA, he there initiated a R&D group on biocatalysis. From 2003 to 2004 he worked as associate professor at the University of Münster. In 2003 Liese received the Award of Up-and-Coming Teacher in Higher Education in the field of biotechnology (DECHEMA, Germany). Since 2014 he is elected member of the steering committee of the DECHEMA e.V.
Dr. Ulrich Kettling is Global Director and Head of Market Segment Industrial Enzymes at Clariant. Before he was Head of Biotechnology R&D and Global Director Biotechnology and Biorefinery at Clariant and Süd-Chemie. Before joining Süd-Chemie, Dr. Kettling was co-founder and Chief Scientific Officer of Direvo Biotech AG. Dr. Kettling graduated in Biotechnology at the Technical University Braunschweig and obtained his Ph D at the Max Planck Institute for Biophysical Chemistry in Göttingen.
Dr. Garabed Antranikian is Professor at the Hamburg University of Technology, where he is head of the Institute of Technical Microbiology. He studied Biology at the American University in Beirut. At the University of Göttingen he completed his Ph D in Microbiology in 1980 in the laboratory of Professor Gerhard Gottschalk and qualified as a post-doctoral lecturer (Habilitation) in 1988. In 1989 he was appointed to a professorship in Microbiology at the Hamburg University of Technology. He was president of the International Society for Extremophiles and is chief editor of the scientific journal Extremophiles. In 2004 he was awarded the most prestigious prize for environment protection by the president of the Federal Republic of Germany. Since 2007 he is the coordinator of the ’Biocatalysis2021’ Cluster and the ’Biorefinery2021’ Cluster of the Ministry of Education and Research and he is chairman of IBN Industrial Biotechnology North. Since 2011 he is the president of Hamburg University of Technology.
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