Tools, techniques, and progress in cancer biomarkers
discovery
The completion of a number of gene sequencing projects, recent
advances in genomic and proteomic technologies, and the
availability of powerful bioinformatics tools have led to promising
new avenues and approaches in the search for cancer biomarkers.
This book provides a comprehensive overview of current
methodologies and technologies. It discusses biomarker discovery as
a whole, rather than focusing on one specific marker or cancer.
With information on both existing and potential biomarkers, Cancer
Biomarkers: Analytical Techniques for Discovery:
* Provides insights into the current technological platforms for
biomarker discovery, including mass spectrometry combined with
multidimensional chromatography, DIGE, and various chip
technologies
* Includes a detailed discussion of protein networks and protein
phosphorylation in cancer
* Details the use of imaging mass spectrometry, laser capture
microdissection, serial analysis of gene expression, enzyme-linked
immunosorbent assays, protein microarrays, antibody-based
microarrays, and bioinformatics
* Covers the emerging role of surface-enhanced laser desorption
ionization (SELDI) and various tagging and labeling
strategies
* Discusses related regulatory and ethical issues
With a wealth of information that can be applied to a broad
spectrum of biomarker research projects, this is a core reference
for biomarker researchers, scientists working in proteomics and
bioinformatics, pharmaceutical scientists, oncologists,
biochemists, biologists, and chemists.
Om författaren
MAHMOUD H. HAMDAN, Ph D, FInst P, is the head of the Mass Spectrometry and Separation Technologies Laboratory at Glaxo Smith Kline in Verona, Italy. He is a coauthor of Proteomics Today: Protein Assessment and Biomarkers Using Mass Spectrometry, 2D Electrophoresis, and Microarray Technology, also from Wiley.
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